dc.contributor.author | Holota, Marcin | |
dc.contributor.author | Magiera, Jakub | |
dc.contributor.author | Michlewska, Sylwia | |
dc.contributor.author | Kubczak, Malgorzata | |
dc.contributor.author | Sanz del Olmo, Natalia | |
dc.contributor.author | García Gallego, Sandra | |
dc.contributor.author | Ortega Lopez, Paula | |
dc.contributor.author | Mata de la Mata, Francisco Javier de la | |
dc.contributor.author | Ionov, Maksim | |
dc.contributor.author | Bryszewska, Maria | |
dc.date.accessioned | 2019-05-14T13:26:55Z | |
dc.date.available | 2019-05-14T13:26:55Z | |
dc.date.issued | 2019-04-18 | |
dc.identifier.bibliographicCitation | Biomolecules, 2019, v. 9, n. 4, p. 155- | en |
dc.identifier.issn | 2218-273X | |
dc.identifier.uri | http://hdl.handle.net/10017/37505 | en |
dc.description.abstract | Newly synthesized carbosilane copper dendrimers (CCD) with chloride and nitrate surface groups seem to be good candidates to be used as gene and drug carriers in anti-cancer therapy, due to their properties such as size and surface charge. Copper attached to the nanoparticles is an important element of many biological processes and recently their anti-cancer properties have been widely examined. Zeta size and potential, transmission electron microscopy (TEM), circular dichroism (CD), analysis of haemolytic activity, and fluorescence anisotropy techniques were used to characterize copper dendrimers. Additionally, their cytotoxic properties toward normal (PBMC) and cancer (1301; HL-60) cells were examined. All tested dendrimers were more cytotoxic against cancer cells in comparison with normal cells. | en |
dc.description.sponsorship | Comunidad de Madrid | es_ES |
dc.description.sponsorship | Agencia Española de Investigación | es_ES |
dc.description.sponsorship | Junta de Comunidades de Castilla-la Mancha | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.rights | MDPI, 2019 | en |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
dc.subject | copper metallodendrimers | en |
dc.subject | anticancer therapeutic agent | en |
dc.subject | nanocarrier | en |
dc.subject | structure | en |
dc.subject | cytotoxicity | en |
dc.title | In Vitro anticancer properties of copper metallodendrimers | en |
dc.type | info:eu-repo/semantics/article | en |
dc.subject.eciencia | Química | es_ES |
dc.subject.eciencia | Chemistry | en |
dc.contributor.affiliation | Universidad de Alcalá. Departamento de Química Orgánica y Química Inorgánica | es_ES |
dc.date.updated | 2019-05-14T13:24:05Z | |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.identifier.doi | 10.3390/biom9040155 | en |
dc.relation.projectID | info:eu-repo/grantAgreement/JCCM//SBPLY%2F17%2F180501%2F000358/ES/NANOSISTEMAS DENDRÍTICOS POLIFENÓLICOS: APLICACIONES EN COSMÉTICA Y BIOMEDICINA/DENPOLIFEN | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-86224-P/ES/DENDRONIZACION COMO HERRAMIENTA SINTÉTICA DE OBTENCIÓN DE NANOSISTEMAS DENDRÍTICOS ESPECIFICAMENTE DISEÑADOS PARA SU USO EN APLICACIONES BIOMÉDICAS | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/CAM/Programas de Actividades de I+D entre Grupos de Investigación de la Comunidad de Madrid en Biomedicina/B2017%2FBMD-3733/ES/INMUNIDAD TUMORAL E INMUNOTERAPIA DEL CANCER/IMMUNOTHERCAN-CM | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
dc.identifier.uxxi | AR/0000030760 | |
dc.identifier.publicationtitle | Biomolecules | |
dc.identifier.publicationvolume | 9 | |
dc.identifier.publicationissue | 4 | |
dc.identifier.publicationfirstpage | 155 | |