In Vitro anticancer properties of copper metallodendrimers
Authors
Holota, Marcin; Magiera, Jakub; Michlewska, Sylwia; Kubczak, Malgorzata; Sanz del Olmo, Natalia; [et al.]Identifiers
Permanent link (URI): http://hdl.handle.net/10017/37505DOI: 10.3390/biom9040155
ISSN: 2218-273X
Date
2019-04-18Funders
Comunidad de Madrid
Agencia Española de Investigación
Junta de Comunidades de Castilla-la Mancha
Bibliographic citation
Biomolecules, 2019, v. 9, n. 4, p. 155-
Keywords
copper metallodendrimers
anticancer therapeutic agent
nanocarrier
structure
cytotoxicity
Project
info:eu-repo/grantAgreement/JCCM//SBPLY%2F17%2F180501%2F000358/ES/NANOSISTEMAS DENDRÍTICOS POLIFENÓLICOS: APLICACIONES EN COSMÉTICA Y BIOMEDICINA/DENPOLIFEN
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-86224-P/ES/DENDRONIZACION COMO HERRAMIENTA SINTÉTICA DE OBTENCIÓN DE NANOSISTEMAS DENDRÍTICOS ESPECIFICAMENTE DISEÑADOS PARA SU USO EN APLICACIONES BIOMÉDICAS
info:eu-repo/grantAgreement/CAM/Programas de Actividades de I+D entre Grupos de Investigación de la Comunidad de Madrid en Biomedicina/B2017%2FBMD-3733/ES/INMUNIDAD TUMORAL E INMUNOTERAPIA DEL CANCER/IMMUNOTHERCAN-CM
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
MDPI, 2019
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Access rights
info:eu-repo/semantics/openAccess
Abstract
Newly synthesized carbosilane copper dendrimers (CCD) with chloride and nitrate surface groups seem to be good candidates to be used as gene and drug carriers in anti-cancer therapy, due to their properties such as size and surface charge. Copper attached to the nanoparticles is an important element of many biological processes and recently their anti-cancer properties have been widely examined. Zeta size and potential, transmission electron microscopy (TEM), circular dichroism (CD), analysis of haemolytic activity, and fluorescence anisotropy techniques were used to characterize copper dendrimers. Additionally, their cytotoxic properties toward normal (PBMC) and cancer (1301; HL-60) cells were examined. All tested dendrimers were more cytotoxic against cancer cells in comparison with normal cells.
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