In Vitro anticancer properties of copper metallodendrimers
AuthorsHolota, Marcin; Magiera, Jakub; Michlewska, Sylwia; Kubczak, Malgorzata; Sanz del Olmo, Natalia; [et al.]
IdentifiersPermanent link (URI): http://hdl.handle.net/10017/37505
Biomolecules, 2019, v. 9, n. 4, p. 155-
anticancer therapeutic agent
CTQ2017-86224-P (MINECO); Consorcio IMMUNOTHERCAN-CM B2017/BMD-3733 (Comunidad de Madrid); CIBER-BBN; SBPLY/17/180501/000358 (Junta de Comunidades de Castilla-la Mancha).
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Newly synthesized carbosilane copper dendrimers (CCD) with chloride and nitrate surface groups seem to be good candidates to be used as gene and drug carriers in anti-cancer therapy, due to their properties such as size and surface charge. Copper attached to the nanoparticles is an important element of many biological processes and recently their anti-cancer properties have been widely examined. Zeta size and potential, transmission electron microscopy (TEM), circular dichroism (CD), analysis of haemolytic activity, and fluorescence anisotropy techniques were used to characterize copper dendrimers. Additionally, their cytotoxic properties toward normal (PBMC) and cancer (1301; HL-60) cells were examined. All tested dendrimers were more cytotoxic against cancer cells in comparison with normal cells.
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