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Pancreatic changes in somatostatin content and receptor-effector system after intrapancreatic injection of 5,7-dihydroxytryptamine

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Authors
Muñoz Acedo, Gema; Álvaro Alonso, Itziar; Arilla Ferreiro, EduardoUniversity of Alcalá Author
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/3216
DOI: 10.1677/joe.0.1450227
ISSN: 0022-0795
Date
1995
Affiliation
Universidad de Alcalá. Departamento de Bioquímica y Biología Molecular
Funders
Dirección General de Investigación Científica y Técnica
Bibliographic citation
Journal of Endocrinology, 1995, v. 145, p. 227-234
Keywords
Acinar cells
Guinea pig
Adenylate cyclase
Amylase secretion
Exocrine pancreas
5-HT1P receptors
Rat brain
Binding
Identification
Forskolin
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1677/joe.0.1450227
Rights
© Journal of Endocrinology Ltd, 1995
Access rights
info:eu-repo/semantics/openAccess
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Abstract
To date, it is unknown whether intrapancreatic serotonergic nerves can influence pancreatic somatostatin (SS) content and the SS receptor/effector system in the exocrine pancreas. In this study, the intrapancreatic serotonergic nerves were chemically ablated by injecting a specific serotonin (5-HT) neurotoxin, 5,7-dihydroxytryptamine (5,7-DHT), into the substance of the gland. Three days after the injection, the 5-HT-like immunoreactive levels in the pancreas were reduced by more than 85% whereas somatostatin-like immunoreactive levels had increased (86%). The number of SS receptors in the pancreatic acinar cell membranes of the 5,7-DHT-treated rats was also increased (72%). No significant differences were seen in basal or forskolin-stimulated adenylate cyclase (AC) enzyme activities in the control and the 5,7-DHT-treated groups. In spite of the increase in the number of SS receptors in the pancreatic acinar cell membranes of 5,7-DHT-treated rats, SS caused a significantly lower inhibition of AC activity in these membranes. This finding is related to the observed decrease of a 41 kD pertussis toxin-sensitive substrate, presumably the αi subunit of the guanine nucleotide inhibitory protein, in pancreatic acinar cell membranes 3 days after intrapancreatic 5,7-DHT administration when compared with the corresponding controls. The functions of pancreatic serotonergic nerves seem to be associated with enteropancreatic communication. These data together with the present results suggest that pancreatic SS content and the SS receptor/effector system in the exocrine pancreas may be regulated by enteropancreatic serotonergic nerve fibers and may participate in enteropancreatic reflexes.
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