New mechanisms involved in the development of cardiovascular disease in chronic kidney disease
Authors
Alique Aguilar, Matilde; Figuer Rubio, Andrea; Valera, Gemma; Serroukh, Nadia; Ceprían, Noemí; [et al.]Identifiers
Permanent link (URI): http://hdl.handle.net/10017/60717DOI: 10.1016/j.nefroe.2023.05.014
ISSN: 02116995
Date
2023-02-01Bibliographic citation
NEFROLOGIA, 2023, v. 43, n. 1, p. 63-80
Keywords
Vascular calcification
Endothelial dysfunction
Cardiovascular disease
Chronic kidney disease
Microvesicles
Extracellular vesicles
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
© Sociedad Española de Nefrología
Access rights
info:eu-repo/semantics/openAccess
Abstract
Chronic kidney disease (CKD) is a pathology with a high worldwide incidence and an upward trend affecting the elderly. When CKD is very advanced, the use of renal replacement therapies is required to prolong its life (dialysis or kidney transplantation). Although dialy-sis improves many complications of CKD, the disease does not reverse completely. These patients present an increase in oxidative stress, chronic inflammation and the release of extracellular vesicles (EVs), which cause endothelial damage and the development of dif-ferent cardiovascular diseases (CVD). CKD patients develop premature diseases associated with advanced age, such as CVD. EVs play an essential role in developing CVD in patients with CKD since their number increases in plasma and their content is modified. The EVs of patients with CKD cause endothelial dysfunction, senescence and vascular calcification. In addition, miRNAs free or transported in EVs together with other components carried in these EVs promote endothelial dysfunction, thrombotic and vascular calcification in CKD, among other effects. This review describes the classic factors and focuses on the role of new mechanisms involved in the development of CVD associated with CKD, emphasizing the role of EVs in the development of cardiovascular pathologies in the context of CKD. Moreover, the review summarized the EVs' role as diagnostic and therapeutic tools, acting on EV release or content to avoid the development of CVD in CKD patients
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Figuer_2023_Nefrologia.pdf | 1.402Mb |
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Figuer_2023_Nefrologia.pdf | 1.402Mb |
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