Antitumoral effects of vasoactive intestinal peptide in human renal cell carcinoma xenografts in athymic nude mice
Authors
Vacas Oliva, Eva; Arenas Jiménez, María Isabel; Muñoz Moreno, Laura; Bajo Chueca, Ana María; Sánchez Chapado, Manuel; [et al.]Identifiers
Permanent link (URI): http://hdl.handle.net/10017/59774DOI: doi: 10.1016/j.canlet.2013.04.033
ISSN: 0304-3835
Date
2013-08-09Affiliation
Universidad de Alcalá. Departamento de Bioquímica y Biología Molecular; Universidad de Alcalá. Departamento de Biología de SistemasFunders
Ministerio de Ciencia e Innovación
Junta de Comunidades de Castilla-La Mancha
Fundación Mutua Madrileña
Fundación Jesús Serra (Grupo Catalana de Occidente)
Bibliographic citation
Cancer Letters, 2013, v. 1, n. 336, p. 196-203
Keywords
VIP
MMP
VEGF
NFKB
ccRCC
Project
info:eu-repo/grantAgreement/MICINN//SAF2007-63794/ES
info:eu-repo/grantAgreement/JCCM//PII-1%2F09-0061-3802/ES
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/aceptedVersion
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
© Elsevier
Access rights
info:eu-repo/semantics/openAccess
Abstract
We studied antitumor effect of VIP in human renal cell carcinoma (RCC) (A498 cells xenografted in immunosuppressed mice). VIP-treated cells gave resulted in p53 upregulation and decreased nuclear ?-catenin translocation and NFKB expression, MMP-2 and MMP-9 activities, VEGF levels and CD-34 expression. VIP led to a more differentiated tubular organization in tumours and less metastatic areas. Thus, VIP inhibits growth of A498-cell tumours acting on the major issues involved in RCC progression such as cell proliferation, microenvironment remodelling, tumour invasion, angiogenesis and metastatic ability. These antitumoral effects of VIP offer new therapeutical possibilities in RCC treatment.
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Antitumoral_Vacas_CanLett_2013.pdf | 1.219Mb |
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Antitumoral_Vacas_CanLett_2013.pdf | 1.219Mb |
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