Effect of Carbamazepine, Ibuprofen, Triclosan and Sulfamethoxazole on Anaerobic Bioreactor Performance: Combining Cell Damage, Ecotoxicity and Chemical Information
Authors
Díaz Cubilla, Felicia Mabel; Letón García, Pedro; Luna Vázquez, Carlos Andrés; Marrón Romera, Marta; Boltes Espínola, Ana KarinaIdentifiers
Permanent link (URI): http://hdl.handle.net/10017/59721DOI: 10.3390/toxics10010042
ISSN: 2305-6304
Date
2022-01-17Affiliation
Universidad de Alcalá. Departamento de Electrónica; Universidad de Alcalá. Departamento de Química Analítica, Química Física e Ingeniería QuímicaFunders
Comunidad de Madrid
Universidad de Alcalá
Bibliographic citation
Toxics, 2022, v. 10, n. 1, p. 1-17
Keywords
anaerobic
pharmaceuticals and personal care products
toxicity
cell damage
enzymatic activity
image analysis
Project
info:eu-repo/grantAgreement/CAM//2018%2FEMT-4341/ES/REMTAVARES
info:eu-repo/grantAgreement/UAH//CCG19%2FIA-050/ES/TOXIVIEW
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
© The Authors
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Access rights
info:eu-repo/semantics/openAccess
Abstract
Pharmaceuticals and personal care products (PPCPs) are partially degraded in wastewater treatment plants (WWTPs), thereby leading to the formation of more toxic metabolites. Bacterial populations in bioreactors operated in WWTPs are sensitive to different toxics such as heavy metals and aromatic compounds, but there is still little information on the effect that pharmaceuticals exert on their metabolism, especially under anaerobic conditions. This work evaluated the effect of selected pharmaceuticals that remain in solution and attached to biosolids on the metabolism of anaerobic biomass. Batch reactors operated in parallel under the pressure of four individual and mixed PPCPs (carbamazepine, ibuprofen, triclosan and sulfametoxazole) allowed us to obtain relevant information on anaerobic digestion performance, toxicological effects and alterations to key enzymes involved in the biodegradation process. Cell viability was quantitatively evaluated using an automatic analysis of confocal microscopy images, and showed that triclosan and mixed pollutants caused higher toxicity and cell death than the other individual compounds. Both individual pollutants and their mixture had a considerable impact on the anaerobic digestion process, favoring carbon dioxide production, lowering organic matter removal and methane production, which also produced microbial stress and irreversible cell damage.
Files in this item
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Effect_Diaz_Toxics_2022.pdf | 4.514Mb |
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Effect_Diaz_Toxics_2022.pdf | 4.514Mb |
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