Characteristics and prognosis of COVID-19 in patients with COPD.
Authors
Graziani , Desirée; Soriano , Joan B; Del Rio-Bermudez , Carlos; Morena , Diego; Diaz , Teresa; [et al.]Identifiers
Permanent link (URI): http://hdl.handle.net/10017/59414DOI: 10.3390/jcm9103259
ISSN: 2077-0383
Date
2020-10-12Bibliographic citation
Journal of Clinical Medicine, 2020, v. 9, n. 10, p. -
Keywords
COPD
COVID-19
Prevalence
Prognosis
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
Attribution 4.0 International (CC BY 4.0)
Access rights
info:eu-repo/semantics/openAccess
Abstract
Patients with Chronic Obstructive Pulmonary Disease (COPD) have a higher prevalence
of coronary ischemia and other factors that put them at risk for COVID-19-related complications.
We aimed to explore the impact of COVID-19 in a large population-based sample of patients with
COPD in Castilla-La Mancha, Spain. We analyzed clinical data in electronic health records from
1 January to 10 May 2020 by using Natural Language Processing through the SAVANA Manager® clinical platform. Out of 31,633 COPD patients, 793 had a diagnosis of COVID-19. The proportion of patients with COVID-19 in the COPD population (2.51%; 95% CI 2.33–2.68) was significantly higher than in the general population aged >40 years (1.16%; 95% CI 1.14–1.18); p < 0.001. Compared with COPD-free individuals, COPD patients with COVID-19 showed significantly poorer disease prognosis, as evaluated by hospitalizations (31.1% vs. 39.8%: OR 1.57; 95% CI 1.14–1.18) and mortality
(3.4% vs. 9.3%: OR 2.93; 95% CI 2.27–3.79). Patients with COPD and COVID-19 were significantly older (75 vs. 66 years), predominantly male (83% vs. 17%), smoked more frequently, and had more comorbidities than their non-COPD counterparts. Pneumonia was the most common diagnosis among COPD patients hospitalized due to COVID-19 (59%); 19% of patients showed pulmonary infiltrates suggestive of pneumonia and heart failure. Mortality in COPD patients with COVID-19 was associated with older age and prevalence of heart failure (p < 0.05). COPD patients with COVID-19 showed higher rates of hospitalization and mortality, mainly associated with pneumonia. This clinical profile is di_erent from exacerbations caused by other respiratory viruses in the winter season.
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