Resveratrol promotes apoptosis through the induction of dual specificiy phosphatase 1and sensitizes prostate cancer cells to cisplatin
Authors
Martínez Martínez, Desirée; Soto Neira, Altea; Gil-Araujo, Beatriz; Gallego Tamayo, Beatriz; Lasa Benito, Marina; [et al.]Identifiers
Permanent link (URI): http://hdl.handle.net/10017/58825DOI: 10.1016/j.fct.2018.12.014
ISSN: 0278-6915
Date
2019-02-01Affiliation
Universidad de Alcalá. Departamento de Bioquímica y Biología Molecular; Universidad de Alcalá. Departamento de Biología de SistemasFunders
Instituto de Salud Carlos III
Universidad Autónoma de Madrid
Ministerio de Economía, Comercio y Empresa
Bibliographic citation
Martínez-Martínez D, Soto A, Gil-Araujo B, Gallego B, Chiloeches A, Lasa M. Resveratrol promotes apoptosis through the induction of dual specificity phosphatase 1 and sensitizes prostate cancer cells to cisplatin. Food Chem Toxicol. 2019;124:273-279.
Keywords
DUSP1
Resveratrol
Cisplatin
Apoptosis
Prostate cancer
Description / Notes
7 p.
Project
info:eu-repo/grantAgreement/ISCIII//PI070832/ES//
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
© Published by Elsevier
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Access rights
info:eu-repo/semantics/openAccess
Abstract
Resveratrol is a polyphenol with chemopreventive properties against prostate cancer; however, the mechanisms
underlying its actions are not completely understood. Previously, we demonstrated that DUSP1 induces apoptosis
in prostate cancer cells; therefore in the present study we investigated the role of this phosphatase on resveratrol
effects. Moreover, we analysed the efficiency of combined treatment of resveratrol and the chemotherapeutic drug
cisplatin on cellular viability and apoptosis and its relation with DUSP1 in prostate cancer cells. We found that
resveratrol up-regulates DUSP1 expression in androgen-independent prostate cancer cells, which in turn, is in volved in the inhibition of the NF-κB pathway and Cox-2 expression. This phosphatase is required for the induction
of apoptosis achieved by resveratrol, but does not regulate the effects of this compound on cell cycle. Furthermore,
we show that resveratrol cooperates with cisplatin both in the up-regulation of DUSP1 levels and in the promotion
of apoptosis, suggesting that DUSP1 is a major determinant of cisplatin sensitivity to apoptosis. These results reveal
a novel molecular mechanism by which resveratrol induces apoptosis in prostate cancer cells, and highlight the
importance of DUSP1 in future therapeutic approaches based in the use of this polyphenol and cisplatin.
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resveratrol_martinez_FOODCHEMT ... | 1.277Mb |
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