Circulating myokines IL-6, IL-15 and FGF21 response to training is altered by exercise type but not by menopause in women with obesity
Authors
Pérez López, Alberto; Gonzalo Encabo, Paola; Pérez Köhler, Bárbara; García Honduvilla, Natalio Antonio; Valadés Cerrato, DavidIdentifiers
Permanent link (URI): http://hdl.handle.net/10017/58601DOI: 10.1080/17461391.2021.1939430
ISSN: 1746-1391
Date
2022-09-22Affiliation
Universidad de Alcalá. Departamento de Medicina y Especialidades Médicas; Universidad de Alcalá. Departamento de Ciencias BiomédicasFunders
Universidad de Alcalá
Bibliographic citation
Alberto Pérez-López, Paola Gonzalo-Encabo, Bárbara Pérez-Köhler, Natalio García-Honduvilla & David Valadés (2022) Circulating myokines IL-6, IL-15 and FGF21 response to training is altered by exercise type but not by menopause in women with obesity, European Journal of Sport Science, 22:9, 1426-1435.
Keywords
Myokines
Inflammation
Endurance and concurrent training
Menopause
Body composition
Physical activity
Description / Notes
24 p.
Project
info:eu-repo/grantAgreement/UAH// CCG2015%BIO-069/ES//
info:eu-repo/grantAgreement/UAH// CCGP2017-BIO%047/ES//
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Access rights
info:eu-repo/semantics/openAccess
Abstract
Objective: To examine the effects of a time-matched endurance versus concurrent training on circulating IL-6, IL-13, IL-15, IL-15Ra, FGF21 levels in postmenopausal women with obesity, and to determine these myokines response to endurance training pre- and postmenopause. Methods: Thirty-five sedentary postmenopausal women with obesity were randomly divided into endurance training (EN1, N=10), concurrent training (CON, N=13) or no training group (CT, N=12). Additionally, twelve sedentary premenopausal women with obesity were added to an endurance training group (EN2, N=12). Participants took part in a 12-week supervised intervention, performing 3 sessions/week of 60 min/session. Before and after the interventions, body composition and fitness were assessed, and blood samples obtained to measure serum myokines levels. Results: Total fat mass decreased in all exercised groups (CON,-5.2%; EN1,-5.3%; EN2,-5.6%). In postmenopausal women, serum IL-6, IL-15 and IL-15Ra decreased after training (P<0.01), finding a pronounced reduction in IL-6 (-42% vs. -16%) and IL-15 (- 50% vs. -31%) when comparing EN1 to CON (P<0.05). Serum FGF21 was only reduced in the EN1 (-27%; P=0.012). While EN1 and EN2 comparison, reported differences for IL-15R? concentration (-28% vs. -40%; P=0.023). Finally, in EN2, the delta change of fat mass and IL-6, IL-15 and IL-15R? were associated (r=0.605; r=0.546; r=0.515; P<0.05). IL-13 showed undetected concentrations. Conclusions: Circulating IL-6, IL-15 and FGF21 response to training is altered by exercise type but not by menopause in women with obesity. Endurance training promotes a higher reduction of these myokines, potentially activating their intricate immune and fat mass regulation roles in postmenopausal women with obesity.
Files in this item
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circulating_perez_EJSC_2021.pdf | 1.246Mb |
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circulating_perez_EJSC_2021.pdf | 1.246Mb |
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