Analysis of effective connectivity between dorsal horn neurons and primary afferents from adult mice [Póster]
Date
2022-07-09Funders
Universidad de Alcalá
Bibliographic citation
Lucas-Romero, J., Rivera-Arconada, I., López-García, J.A. Analysis of effective connectivity between dorsal horn neurons and primary afferents from adult mice. Póster presentado en: FENS Forum 2022, International Neuroscience Conference; 2022 july 9-13; Paris, France
Description / Notes
FENS Forum 2022, International Neuroscience Conference, 9-13 july 2022, Paris, France
Project
info:eu-repo/grantAgreement/UAH//CCG2018%BIO-028/ES//
info:eu-repo/grantAgreement/UAH//PIUAH21%CC-039/ES//
Document type
info:eu-repo/semantics/conferenceObject
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Access rights
info:eu-repo/semantics/openAccess
Abstract
Primary afferent depolarization (PAD) is the mechanism underlying presynaptic inhibition as first described in the ventral horn of the spinal cord. Primary afferents have abnormally high concentrations of Cl- ions, presumably due to
the activity of the chloride transporter NKCC1. Activation of GABAA receptors causes an outflow of Cl-, which leads to PAD. PAD occurs in the dorsal horn as well, where it may serve as a mechanism of sensory modulation. Under certain conditions PAD may be enhanced reaching action potential
threshold to produce dorsal root reflexes (DRR) or backfiring in primary afferents.
Here we set out to study the dorsal horn neurons and circuits that generate backfiring in primary afferents. To this purpose we obtained simultaneous recordings from sets of dorsal horn neurons and primary afferents and used an AI algorithm to
analyze the obtained spike trains.
Files in this item
Files | Size | Format |
|
---|---|---|---|
analisis_lucas_FENS_2022.pdf | 1001.Kb |
|
Files | Size | Format |
|
---|---|---|---|
analisis_lucas_FENS_2022.pdf | 1001.Kb |
|