Visible-light mediated synthesis of bicalutamide by regioselective hydroxysulfonylation of acrylamides
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/57892DOI: 10.1002/ejoc.202300535
ISSN: 1434-193X
Date
2023-08-04Affiliation
Química Orgánica y Química InorgánicaFunders
European Union
Comunidad de Madrid
Universidad de Alcalá
Bibliographic citation
European Journal of Organic Chemistry, 2023, p. 1-5
Project
info:eu-repo/grant/Agreement/CAM//2018-T1%2FIND-10054/
info:eu-repo/grant/Agreement/CAM//2020-T2%2FBMD-20391/
info:eu-repo/grant/Agreement/EC/46-UAH-INV/EU/
info:eu-repo/grant/Agreement/UAH//PIUAH21%2FCC-003
info:eu-repo/grant/Agreement/UAH/CCG20%2FCC-009
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
© The Authors
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Access rights
info:eu-repo/semantics/openAccess
Abstract
Synthesis of anticancer drug bicalutamide promoted by visible light in one step from the corresponding N-arylacrylamide is described. This approach involves a one-pot hydroxysulfonylation reaction through a photocatalytic redox process. The use of Na2Eosin Y as photocatalyst and blue light allows the access to a broad range of alfa-hydroxysulfonylamides bearing a quaternary center in moderate to good yields with complete regioselectivity via radical process.
Files in this item
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EurJOC_2023.pdf | 3.718Mb |
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Files | Size | Format |
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EurJOC_2023.pdf | 3.718Mb |
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