Antioxidant and Antibacterial Properties of Carbosilane Dendrimers Functionalized with Polyphenolic Moieties
Authors
Sanz del Olmo, Natalia; Peña González, Cornelia Emeritina; Rojas Tizón, José Daniel; Gómez Ramírez, Rafael; Ortega Lopez, Paula; [et al.]Identifiers
Permanent link (URI): http://hdl.handle.net/10017/57712DOI: doi.org/10.3390/pharmaceutics12080698
ISSN: 1999-4923
Date
2020-07-21Funders
Ministerio de Economía y Competitividad
Junta de Comunidades de Castilla-La Mancha
Comunidad de Madrid
Bibliographic citation
Pharmaceutics, 2020, v. 12, n. 698
Keywords
antioxidants
polyphenols
carbosilane dendrimers
antibacterial
Project
info:eu-repo/grantAgreement/MINECO/CTQ2017-86224-P/ES//
info:eu-repo/grantAgreement/JCCM//SBPLY%2F17%2F180501/ 000358/ES//
info:eu-repo/grantAgreement/CAM//B2017%2FBMD-3703/ES//
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
© The authors
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Access rights
info:eu-repo/semantics/openAccess
Abstract
A new family of polyphenolic carbosilane dendrimers functionalized with ferulic, caffeic, and gallic acids has been obtained through a straightforward amidation reaction. Their antioxidant activity has been studied by different techniques such as DPPH (2,2 '-diphenyl-1-picrylhydrazyl) radical scavenging assay, FRAP assay (ferric reducing antioxidant power), and cyclic voltammetry. The antioxidant analysis showed that polyphenolic dendrimers exhibited higher activities than free polyphenols in all cases. The first-generation dendrimer decorated with gallic acid stood out as the best antioxidant compound, displaying a correlation between the number of hydroxyl groups in the polyphenol structure and the antioxidant activity of the compounds. Moreover, the antibacterial capacity of these new systems has been screened against Gram-positive (+) and Gram-negative (-) bacteria, and we observed that polyphenolic dendrimers functionalized with caffeic and gallic acids were capable of decreasing bacterial growth. In contrast, ferulic carbosilane dendrimers and free polyphenols showed no effect, establishing a correlation between antioxidant activity and antibacterial capacity. Finally, a viability assay in human skin fibroblasts cells (HFF-1) allowed for corroborating the nontoxicity of the polyphenolic dendrimers at their active antibacterial concentration.
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