Show simple item record

dc.contributor.authorRodríguez Sánchez, María Nelly
dc.contributor.authorArilla Ferreiro, Eduardo 
dc.date.accessioned2009-06-08T19:21:23Z
dc.date.available2009-06-08T19:21:23Z
dc.date.issued1991
dc.identifier.bibliographicCitationNeuroscience letters, 1991, v. 134, n. 1, p. 37-40en
dc.identifier.issn0304-3940
dc.identifier.urihttp://hdl.handle.net/10017/3106
dc.description.abstractPrimiparous female Wistar rats were injected subcutancously with single daily doses of 40 mg of cocaine hydrochloride/kg from day 7 to 19 of gestation, from day 7 of gestation to day 15 postpartum or from parturation to day 15 postpartum. At birth, some of the offspring were fostered to control mothers to limit the effect of cocaine to the prenatal period and some were left with their mothers with the aim of studying prenatal plus postnatal exposure to cocaine. Prenatal and/or postnatal cocaine exposure did not affect the content of somatostatin (SS)-like iminunoreactivity (SLI) in the striatum of the offspring as compared with the control groups on day 15 in all experimental groups. Prenatal and prenatal-plus-postnatal exposure to cocaine increased the total number of binding sites for 125I-Tyr11-SS in the rat striatum at 15 days of age. Prenatal exposure to cocaine also decreased the apparent affinity of the receptors. Postnatal exposure to cocaine alone had no such post-treatment effect on 125I-Tyr11-SS binding. These results suggest that the development of SS receptors in the rat striatum can be altered by prenatal exposure to cocaine.en
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherElsevieren
dc.rights© Elsevier Scientific Publishers Ireland, 1991en
dc.subjectCocaineen
dc.subjectSomatostatinen
dc.subjectOffspringen
dc.subjectRaten
dc.subjectReceptoren
dc.subjectStriatumen
dc.titleChanges in striatal somatostatin receptors in pups after cocaine administration to pregnant and nursing damsen
dc.typeinfo:eu-repo/semantics/articleen
dc.subject.ecienciaBioquímicaes_ES
dc.subject.ecienciaBiochemistryen
dc.subject.ecienciaScienceen
dc.subject.ecienciaCienciaes_ES
dc.contributor.affiliationUniversidad de Alcalá. Departamento de Bioquímica y Biología Molecular
dc.relation.publisherversionhttp://dx.doi.org/10.1016/0304-3940(91)90503-L
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1016/0304-3940(91)90503-L
dc.relation.projectIDPB87-0753 (Comisión Interministerial de Ciencia y Tecnología-CICYT)
dc.relation.projectID88/0903 (Fondo de Investigaciones Sanitarias-FIS)
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen


Files in this item

Thumbnail

This item appears in the following Collection(s)