Cysteamine normalizes cerebral somatostatin level and binding in pentylenetetrazol-kindled rats
Authors
Pérez Oso, E.; López Ruiz, María del Pilar; González Guijarro, Luis A.; Arilla Ferreiro, EduardoIdentifiers
Permanent link (URI): http://hdl.handle.net/10017/2979DOI: 10.1016/0024-3205(89)90010-6
Publisher
Pergamon Press
Date
1989Funders
Comisión Interministerial de Ciencia y Tecnología-CICYT
Instituto de Salud Carlos III
Bibliographic citation
Life Sciences, 1989, v. 45, n. 25, p. 2451-2458
Keywords
Cysteamine
Rat
Pentylenetetrazol
Somatostatin
Project
info:eu-repo/grantAgreement/CICYT//PB87-0753/ES/ESTUDIO DE LAS BASES MOLECULARES DE INHIBICIÓN DE LA PROLIFERACIÓN CELULAR INDUCIDA POR LA SOMATOSTATINA
info:eu-repo/grantAgreement/ISCIII//88%2F0903/ES//
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1016/0024-3205(89)90010-6Rights
© 1989 Elsevier Inc.
Access rights
info:eu-repo/semantics/openAccess
Abstract
Rats were kindled by intraperitoneal injection of pentylenetetrazol (PTZ) (30 mg/Kg) every 48 h. Once kindled, some of the animals received a single injection of cysteamine (200 mg/Kg). Somatostatin-like immunoreactivity (SLI) and 125 I-Tyr11 -somatostatin binding were measured in the frontoparietal cortex and hippocampus of the two experimental groups and the control rats. After PTZ kindling the following was observed: 1) SLI content was increased in the two areas; 2) Somatostatin receptor affinity decreased in the frontoparietal cortex and was unaltered in the hippocampus; 3) The number of somatostatin receptors decreased in the hippocampus and was unaltered in the frontoparietal cortex. Cysteamine, an agent which depletes brain somatostatin and suppresses kindled seizures in PTZ-treated rats, reversed the altered SLI levels and binding in these rats.
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