RT info:eu-repo/semantics/article
T1 A Sustainable Approach for Extracting Non-Extractable Phenolic Compounds from Mangosteen Peel Using Ultrasound-Assisted Extraction and Natural Deep Eutectic
Solvents
A1 Marina Alegre, María Luisa
A1 Plaza del Moral, Merichel
A1 Domínguez Rodríguez, Gloria
A1 Sahelices Garrido-Lestache, Cristina
K1 natural deep eutectic solvent
K1 sustainable extraction
K1 non-extractable polyphenols
K1 mangosteen peel
K1 ultrasound-assisted extraction
K1 response surface methodology
K1 Química
K1 Chemistry
AB Mangosteen (Garcinia mangostana L.) peel is a potential source of phenolic compounds with beneficial properties. Natural deep eutectic solvents (NaDES) have beenconsidered an environmentally friendly and cheap alternative to conventionalorganic solvents. In this work, a green extraction methodology was developedusing ultrasound-assisted extraction (UAE) and NaDES for the extraction ofantioxidant non-extractable polyphenols (NEPs) from mangosteen peel. To selectthe best NaDES to extract NEPs from mangosteen peel, seven NaDES were studied.Antioxidant capacity and total phenolic and proanthocyanidin contents weredetermined for the extracts. The molecular weights for the NEPs present inthose extracts were evaluated by size exclusion chromatography. Experimentalresults showed that choline chloride&-lactic acid (1:2) was the NaDES allowingthe highest antioxidant proanthocyanidin content in the extracts. A Box&-Behnkenexperimental design was employed to optimize the main parameters in UAE withNaDES: water percentage, ultrasound amplitude, and extraction time. The optimalextraction conditions were 18.8% (v/v) water, 60% ultrasound amplitude, and 15min as the extraction time. In addition, the cytotoxicity of the NEP extractsobtained under optimal extraction conditions was evaluated. Results indicatedfor the first time that the use of NaDES in combination with UAE could be asustainable alternative for the extraction of antioxidant NEPs from mangosteenpeel for important applications in the food, pharmaceutical, agrochemical, andcosmetic fields, as the extracts presented low cytotoxicity.
SN 2076-3417
YR 2021
FD 2021-06-18
LK http://hdl.handle.net/10017/48667
UL http://hdl.handle.net/10017/48667
LA eng
DS MINDS@UW
RD 01-may-2024