RT info:eu-repo/semantics/article
T1 Enantiomeric determination of drugs in pharmaceutical formulations and biological samples by Electrokinetic Chromatography
A1 Marina Alegre, María Luisa
A1 García González, María Ángeles
A1 Casado Navas, Natalia
A1 Valimaña Traverso, Jesús Manuel
K1 Biological samples
K1 chiral selectors
K1 drugs
K1 electrokinetic chromatography
K1 enantiomers pharmaceutical formulations
K1 Química
K1 Chemistry
AB Chirality is a relevant issue in the pharmaceutical field due to the different biological activity that enantiomers of a chiral drug can show. In fact, the desired biological or pharmaceutical activity might be present in only one of the enantiomers, while the other enantiomer(s) may have different biological activity, be inactive or even toxic. This has motivated in recent years the development of drugs marketed as pure enantiomers to avoid exposing the organism to the action of enantiomers that may not be active or even harmful to health. Thus, it is of high interest to develop enantioselective analytical methodologies to control the presence of enantiomeric impurities and to understand the enantioselective metabolism of chiral drugs. This review gives an overview about the analytical strategies developed by electrokinetic chromatography (EKC) from 2010 to June 2019 for the enantiomeric determination of drugs in both pharmaceutical formulations and biological samples. The types of chiral selectors used, the migration order of enantiomers, their resolution, the detection technique employed and the sensitivity achieved are revised and compared. Also, applications to assess the enantiomeric purity control of pharmaceutical formulations and to determine chiral drugs in biological samples to study their metabolism are included. Advantages and limitations of the chiral methods developed by EKC are also discussed.
SN 1040-8347
YR 2020
FD 2020-11-01
LK http://hdl.handle.net/10017/47788
UL http://hdl.handle.net/10017/47788
LA eng
DS MINDS@UW
RD 02-may-2024