RT info:eu-repo/semantics/article
T1 In Vitro anticancer properties of copper metallodendrimers
A1 Holota, Marcin
A1 Magiera, Jakub
A1 Michlewska, Sylwia
A1 Kubczak, Malgorzata
A1 Sanz del Olmo, Natalia
A1 García Gallego, Sandra
A1 Ortega Lopez, Paula
A1 Mata de la Mata, Francisco Javier de la
A1 Ionov, Maksim
A1 Bryszewska, Maria
K1 copper metallodendrimers
K1 anticancer therapeutic agent
K1 nanocarrier
K1 structure
K1 cytotoxicity
K1 Química
K1 Chemistry
AB Newly synthesized carbosilane copper dendrimers (CCD) with chloride and nitrate surface groups seem to be good candidates to be used as gene and drug carriers in anti-cancer therapy, due to their properties such as size and surface charge. Copper attached to the nanoparticles is an important element of many biological processes and recently their anti-cancer properties have been widely examined. Zeta size and potential, transmission electron microscopy (TEM), circular dichroism (CD), analysis of haemolytic activity, and fluorescence anisotropy techniques were used to characterize copper dendrimers. Additionally, their cytotoxic properties toward normal (PBMC) and cancer (1301; HL-60) cells were examined. All tested dendrimers were more cytotoxic against cancer cells in comparison with normal cells.
SN 2218-273X
YR 2019
FD 2019-04-18
LK http://hdl.handle.net/10017/37505
UL http://hdl.handle.net/10017/37505
LA eng
NO Comunidad de Madrid
DS MINDS@UW
RD 28-abr-2024