RT info:eu-repo/semantics/article
T1 Synthesis and DNA interaction of ethylenediamine platinum(II) complexes linked to DNA intercalants
A1 Duskova, Katerina
A1 Sierra, Sara
A1 Fernández, María-José
A1 Gude Rodríguez, Lourdes
A1 Lorente, Antonio
K1 Platinum(II) complexes
K1 DNA intercalants
K1 DNA interactions
K1 Ciencia
K1 Química
K1 Science
K1 Chemistry
AB A series of ethylenediamine platinum(II) complexes connected through semi-rigid chains of 1,2-bis(4-pyridyl)ethane to DNA intercalating subunits (naphthalene, anthracene or phenazine) has been synthesized,and their interactions with calf thymus (CT) DNA have been evaluated by viscometric titrationsand equilibrium dialysis experiments. The parent ligands that contain anthracene or phenazine chromophoresshowed a monointercalative mode of DNA interaction (especially the anthracene derivative),with apparent association constants in the order of 104 M 1. The corresponding platinum(II) complexesbind CT DNA through bisintercalation, as established by the significant increase of DNA contour lengthinferred from viscosity measurements, and the association constants are in the order of 105 M 1. Thenaphthalene derivatives, however, exhibit a mixed mode of interaction, which suggests a partial contributionof both intercalation and groove binding for the ligand, and monointercalation in the case of theplatinum(II) complex. Competition dialysis experiments carried out on the intercalative compounds haverevealed a moderate selectivity towards GC DNA sequences for the derivatives containing the anthracenechromophore.
PB Elsevier
SN 0968-0896
YR 2012
FD 2012
LK http://hdl.handle.net/10017/20843
UL http://hdl.handle.net/10017/20843
LA eng
NO Junta de Castilla y León
DS MINDS@UW
RD 29-abr-2024