RT info:eu-repo/semantics/article
T1 DAX-1 expression in human breast cancer: comparison with estrogen receptors ER-α, ER-ß and androgen receptor status
A1 Conde Martín, María Isabel
A1 Alfaro Sánchez, Juan María
A1 Paniagua Gómez-Álvarez, Ricardo
A1 Fraile Laiz, Benito
A1 Arenas Jiménez, María Isabel
K1 Breast cancer
K1 Cáncer de mama
K1 Androgen receptor
K1 DAX-1
K1 Estrogen receptor-α
K1 Estrogen receptor-β
K1 Bioquímica
K1 Biochemistry
K1 Science
K1 Ciencia
AB So far there have been no reports on the expression pattern of DAX-1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1) in human breast cells and its relationship to the estrogen receptors, ER-¿ and ER-ß, and the androgen receptor (AR).In this study we evaluated, by immunohistochemistry and Western blot analysis, the presence and distribution of DAX-1 in benign breast disease (BBD), in situ carcinoma (CIS), and ductal and lobular breast carcinomas.In BBD and breast carcinomas, DAX-1 was present in both the nuclei and the cytoplasm of epithelial cells, although in infiltrative carcinomas the percentage of nuclear immunoreaction was higher than in CIS. An important relation was observed between DAX-1 and AR expression and between this orphan receptor and nodal status.DAX-1 might modify the AR and ER-ß intracellular location, and because a direct positive relation between the expression of these three receptors was found it could be assumed that the presence of DAX-1 in neoplastic cells might indicate a possible failure of endocrine therapies
PB BioMed Central Ltd.
SN 1465-5411
YR 2004
FD 2004
LK http://hdl.handle.net/10017/166
UL http://hdl.handle.net/10017/166
LA eng
NO Universidad de Alcalá
DS MINDS@UW
RD 01-may-2024