In vitro susceptibility of recent antibiotic-resistant urinary pathogens to ertapenem and 12 other antibiotics
Authors
Cuadros González, Juan; Alhambra Mosquera, Almudena; Cacho, J.; Gómez-Garcés, José Luis; Alós Cortes, Juan IgnacioIdentifiers
Permanent link (URI): http://hdl.handle.net/10017/60487DOI: 10.1093/jac/dkh218
ISSN: 1460-2091
Date
2004-06Affiliation
Universidad de Alcalá. Departamento de Biomedicina y Biotecnología. Unidad Docente de MicrobiologíaBibliographic citation
The Journal of antimicrobial chemotherapy, 2004, v. 53, n. , p. 1090-1094
Keywords
Carbapenems
Antibiotic susceptibility
Urinary tract infections
Description / Notes
7 p.
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/acceptedVersion
Rights
© The British Society for Antimicrobial Chemotherapy 2004
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Access rights
info:eu-repo/semantics/openAccess
Abstract
Background: The treatment of complicated urinary tract infections may require the use of a parenteral anti-biotic with potent activity against the most common urinary pathogens. Ertapenem is a broad-spectrum 1?-methyl carbapenem with a long plasma half-life that allows administration of a single daily dose. Methods: The purpose of this work was to test the in vitro susceptibility to ertapenem, ampicillin, cefazolin, cefuroxime, cefotaxime, co-amoxiclav, piperacillin/tazobactam, imipenem, gentamicin, amikacin, fosfo-mycin, ciprofloxacin and co-trimoxazole of 482 strains of urinary pathogens of the family Enterobacteriaceae isolated from patients in the community of Madrid (40% from males). The distribution was as follows: Escherichia coli (n = 315), Proteus mirabilis (n = 42), Klebsiella spp. (n = 14) and AmpC-producing Entero-bacteriaceae (n = 111). The strains studied were selected based on their resistance to quinolones and aminoglycosides, and their production of extended-spectrum ?-lactamases (ESBLs) or AmpC-type ?-lacta-mases. Results: All the strains were susceptible to ertapenem, imipenem and amikacin. The MIC90 of ertapenem ranged from a minimum of 0.03 mg/L for Proteus vulgaris and a maximum of 1 mg/L for Enterobacter spp. Ertapenem was the most active of all drugs tested in all cases. On comparing antibiotic resistance among ESBL-producing strains of E. coli (n = 35) and E. coli strains not producing ESBLs (n = 280), statistically significant differences were obtained for ciprofloxacin (P = 0.002) and gentamicin (P = 0.011). Regarding ertapenem, only a slight increase in MIC50 was seen, the value being 0.015 mg/L for strains not producing ESBLs versus 0.03 mg/L for ESBL-producing strains. Conclusions: In view of its significant antibiotic potency against antibiotic-resistant Enterobacteriaceae, ertapenem may constitute a good therapeutic alternative in urinary infections caused by these pathogens.
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invitro_alhambra_jac_2004.pdf | 393.8Kb |
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