Cytokines-their pathogenic and therapeutic role in chronic viral hepatitis
Authors
Larrubia Marfil, Juan Ramón; Benito Martínez, Selma; Miquel Plaza, Joaquin; Sanz De Villalobos , Eduardo; González Mateos, Fernando; [et al.]Identifiers
Permanent link (URI): http://hdl.handle.net/10017/59272DOI: 10.4321/S1130-01082009000500006
ISSN: 1130-0108
Date
2009Funders
Junta de Comunidades de Castilla-La Mancha
Fundación de Investigación Médica Mutua Madrileña
Bibliographic citation
Revista Espanola de Enfermedades Digestivas, 2009, v. 101, n. 5, p. 343-351
Keywords
Cytokines
Chronic hepatitis
HBV
HCV
Immunopathogenesis
Description / Notes
9 p.
Project
info:eu-repo/grantAgreement/JCCM/Fiscam/PI-2007%32/ES//
info:eu-repo/grantAgreement/FMM//2548%2008/ES//
info:eu-repo/grantAgreement/JCCM/Fiscam/MOV-2007_JI%18/ES//
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Access rights
info:eu-repo/semantics/openAccess
Abstract
Cytokines make up a network of molecules involved in the regulation of immune response and organ functional homeostasis. Cytokines coordinate both physiological and pathological processes occurring in the liver during viral infection, including infection control, inflammation, regeneration, and fibrosis. Hepatitis B and hepatitis C viruses interfere with the complex cytokine network brought about by the immune system and liver cells in order to prevent an effective immune response, capable of viral control. This situation leads to intrahepatic sequestration of nonspecific inflammatory infiltrates that release proinflammatory cytokines, which in turn favor chronic inflammation and fibrosis. The therapeutical administration of cytokines such as interferon alpha may result in viral clearance during persistent infection, and revert this process.
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cytokines_larrubia_REED_2009.pdf | 431.8Kb |
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