Costimulatory molecule PD-1 in the cytotoxic response during chronic hepatitis C
Authors
Larrubia Marfil, Juan Ramón; Benito Martínez, Selma; Miquel Plaza, Joaquin; Calvino Fernández, Mirian; Sanz De Villalobos , Eduardo; [et al.]Identifiers
Permanent link (URI): http://hdl.handle.net/10017/59268DOI: 10.3748/wjg.15.5129
ISSN: 1007-9327
Date
2009Affiliation
Universidad de Alcalá. Departamento de MedicinaFunders
Fundación de Investigación Médica Mutua Madrileña
Instituto de Salud Carlos III
Junta de Comunidades de Castilla-La Mancha
Bibliographic citation
World Journal of Gastroenterology, 2009, v. 15, n. 41, p. 5129-5140
Keywords
Chronic hepatitis
Exhaustion
Hepatitis C virus
Hepatitis C virus core
Programmed death-1
Programmed death-1 ligand
Description / Notes
12 p.
Project
info:eu-repo/grantAgreement/JCCM/Fiscam/PI-2007%32/ES//
info:eu-repo/grantAgreement/FMM//2548%2008/ES//
info:eu-repo/grantAgreement/ISC III//CA07%00157/ES//
info:eu-repo/grantAgreement/JCCM/Fiscam/MOV-2007_JI/18/ES//
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
©2009 The WJG Press and Baishideng
Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0)
Access rights
info:eu-repo/semantics/openAccess
Abstract
Hepatitis C virus (HCV)-specific CD8+ T cells play an important role in the resolution of HCV infection. Nevertheless, during chronic hepatitis C these cells lack their effector functions and fail to control the virus. HCV has developed several mechanisms to escape immune control. One of these strategies is the upregulation of negative co-stimulatory molecules such us programmed death-1 (PD-1). This molecule is upregulated on intrahepatic and peripheral HCV-specific cytotoxic T cells during acute and chronic phases of the disease, whereas PD-1 expression is low in resolved infection. PD-1 expressing HCV-specific CD8+ T cells are exhausted with impairment of several effector mechanisms, such as: type-1 cytokine production, expansion ability after antigen encounter and cytotoxic ability. However, PD-1 associated exhaustion can be restored by blocking the interaction between PD-1 and its ligand (PD-L1). After this blockade, HCV-specific CD8+ T cells reacquire their functionality. Nevertheless, functional restoration depends on PD-1 expression level. High PD-1-expressing intrahepatic HCV-specific CD8+ T cells do not restore their effector abilities after PD-1/ PD-L1 blockade. The mechanisms by which HCV is able to induce PD-1 up-regulation to escape immune control are unknown. Persistent TCR stimulation by a high level of HCV antigens could favour early PD-1 induction, but the interaction between HCV core protein and gC1q receptor could also participate in this process. The PD-1/PD-L1 pathway modulation could be a therapeutic strategy, in conjunction with the regulation of others co-stimulatory pathways, in order to restore immune response against HCV to succeed in clearing the infection.
Files in this item
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costimulatory_larrubia_2009.pdf | 1.249Mb |
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costimulatory_larrubia_2009.pdf | 1.249Mb |
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