Endothelial Senescence and the Chronic Vascular Diseases: Challenges and Therapeutic Opportunities in Atherosclerosis
Autores
Alique Aguilar, Matilde; Ceprían, Noemí; Ramírez Chamond, Manuel Rafael; Figuer Rubio, Andrea; Valera, Gemma; [et al.]Identificadores
Enlace permanente (URI): http://hdl.handle.net/10017/51249DOI: 10.3390/jpm12020215
ISSN: 2075-4426
Fecha de publicación
2022-02-04Patrocinadores
Instituto de Salud Carlos III
Sociedad Española de Nefrología
Comunidad de Madrid
Fondo Europeo de Desarrollo Regional
Cita bibliográfica
Journal of Personalized Medicine, 2022, v. 12, n. 215
Palabras clave
Atherosclerosis
Cellular senescence
Endothelial senescence
Extracellular vesicles
Inflammation
Senolityc
Proyectos
info:eu-repo/grantAgreement/ISCIII//PI19%2F00240
info:eu-repo/grantAgreement/ISCIII//PI17%2F01029
info:eu-repo/grantAgreement/ISCIII//PI20%2F01321
info:eu-repo/grantAgreement/ISCIII//PI20%2F00018
info:eu-repo/grantAgreement/CM-FEDER// PEJ-2020-AI%2FBMD-18141
Tipo de documento
info:eu-repo/semantics/article
Versión
info:eu-repo/semantics/publishedVersion
Derechos
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Derechos de acceso
info:eu-repo/semantics/openAccess
Resumen
Atherosclerosis is probably one of the paradigms of disease linked to aging. Underlying the physiopathology of atherosclerosis are cellular senescence, oxidative stress, and inflammation. These factors are increased in the elderly and from chronic disease patients. Elevated levels of oxidative stress affect cellular function and metabolism, inducing senescence. This senescence modifies the cell phenotype into a senescent secretory phenotype. This phenotype activates immune cells, leading to chronic systemic inflammation. Moreover, due to their secretory phenotype, senescence cells present an increased release of highlighted extracellular vesicles that will change nearby/neighborhood cells and paracrine signaling. For this reason, searching for specific senescent cell biomarkers and therapies against the development/killing of senescent cells has become relevant. Recently, senomorphic and senolityc drugs have become relevant in slowing down or eliminating senescence cells. However, even though they have shown promising results in experimental studies, their clinical use is still yet to be determined
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Colecciones
- FISIOLOG - Artículos [87]