A Transgenic Mouse Model for Studying the Role of the Parathyroid Hormone-Related Protein System in Renal Injury
Authors
Bosch Martínez, Ricardo JoséIdentifiers
Permanent link (URI): http://hdl.handle.net/10017/50439DOI: 10.1155/2011/290874
ISSN: 1110-7243
Date
2010-10-31Funders
Comunidad de Madrid
Ministerio de Educación y Cultura
Ministerio de Ciencia e Innovación
Instituto de Salud Carlos III
Bibliographic citation
Bosch, R.J. et al., 2010. A Transgenic Mouse Model for Studying the Role of the Parathyroid Hormone-Related Protein System in Renal Injury. Journal of biomedicine & biotechnology, 2011, pp.290874-290880
Project
info:eu-repo/grantAgreement/CAM//S-BIO-2083-2006/ES//
info:eu-repo/grantAgreement/MICIN//SAFZ002-04356-C03-01/ES/El sistema de PTHRP renal: un modulador renovascular implicado en los mecanismos de daño/reparación. Estudio en neforpatías humanas y en modelos experimentales
info:eu-repo/grantAgreement/MICINN//SAF2009-12009-C02-01/ES/Estudio Coordinado De Nuevas Moleculas Implicadas En La Diabetes Mellitus: Papel De La Citokina Tweak Y Del Bisfenol A En La Nefropatia Diabetica/
info_eu-repo/grantAgreement/CAM//CAM 08.6%2F0038.1%2F2000-2/ES//
info:eu-repo/grantAgreement/MSC//RD06%2F0013%2F1002/ES/RED TEMÁTICA DE INVESTIGACIÓN COOPERATIVA EN ENVEJECIMIENTO Y FRAGILIDAD (RETICEF)/
info:eu-repo/grantAgreement/CAM//GR%2FSAL%2F0415%2F2004/ES/Papel de la interacción entre la proteína relacionada con la parathormona (PTHRP) y el factor de crecimiento del endotelio vascular (VEGF) en los mecanismos proinflamatorios y profibrogénicos asociados a la nefropatía túbulointersticial
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
Attribution 4.0 International (CC BY 4.0)
© 2011 The Authors
Access rights
info:eu-repo/semantics/openAccess
Abstract
Parathyroid hormone- (PTH-) related protein (PTHrP) and its receptor, the PTH1 receptor (PTH1R), are widely expressed in the kidney, where PTHrP exerts a modulatory action on renal function. PTHrP is known to be upregulated in several experimental nephropathies such as acute renal failure (ARF), obstructive nephropathy (ON) as well as diabetic nephropathy (DN). In this paper, we will discuss the functional consequences of chronic PTHrP overexpression in the damaged kidney using a transgenic mouse strain overexpressing PTHrP in the renal proximal tubule. In both ARF and ON, PTHrP displays proinflammatory and profibrogenic actions including the induction of epithelia to mesenquima transition. Moreover, PTHrP participates in the mechanisms of renal hypertrophy as well as proteinuria in experimental DN. Angiotensin II (Ang II), a critical factor in the progression of renal injury, appears to be, at least in part, responsible for endogenous PTHrP upregulation in these pathophysiological settings. These findings provide novel insights into the well-known protective effects of Ang II antagonists in renal diseases, paving the way for new therapeutic approaches.
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transgenic_bosch_JBB_2010.pdf | 1.269Mb |
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