Novel Perspectives towards RNA-Based Nano-Theranostic Approaches for Cancer Management
Autores
Arshad, Rabia; Fatima, Iqra; Sargazi, Saman; Rahdar, Abbas; Karamzadeh-Jahromi, Milad; [et al.]Identificadores
Enlace permanente (URI): http://hdl.handle.net/10017/50163DOI: https://doi.org/10.3390/nano11123330
ISSN: 2079-4991
Fecha de publicación
2021-12-08Filiación
Universidad de Alcalá. Departamento de Química Analítica, Química Física e Ingeniería QuímicaPatrocinadores
Comunidad de Madrid
Cita bibliográfica
Nanomaterials, 2021, v. 11, n. 12, p. 3330-
Palabras clave
RNA nanotechnology
Cancer
Theranostic
Nano-biosensor
Proyectos
info:eu-repo/grantAgreement/CAM/Estímulo a la Excelencia para Profesores Universitarios Permanentes/EPU-INV%2F2020%2F012/ES/
Tipo de documento
info:eu-repo/semantics/article
Versión
info:eu-repo/semantics/publishedVersion
Derechos
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
MDPI, 2021
Derechos de acceso
info:eu-repo/semantics/openAccess
Resumen
In the fight against cancer, early diagnosis is critical for effective treatment. Traditional cancer diagnostic technologies, on the other hand, have limitations that make early detection difficult. Therefore, multi-functionalized nanoparticles (NPs) and nano-biosensors have revolutionized the era of cancer diagnosis and treatment for targeted action via attaching specified and biocompatible ligands to target the tissues, which are highly over-expressed in certain types of cancers. Advancements in multi-functionalized NPs can be achieved via modifying molecular genetics to develop personalized and targeted treatments based on RNA interference. Modification in RNA therapies utilized small RNA subunits in the form of small interfering RNAs (siRNA) for overexpressing the specific genes of, most commonly, breast, colon, gastric, cervical, and hepatocellular cancer. RNA-conjugated nanomaterials appear to be the gold standard for preventing various malignant tumors through focused diagnosis and delivering to a specific tissue, resulting in cancer cells going into programmed death. The latest advances in RNA nanotechnology applications for cancer diagnosis and treatment are summarized in this review
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