Isolation and characterization of peptides with antihypertensive activity in foodstuffs
Identificadores
Enlace permanente (URI): http://hdl.handle.net/10017/48227DOI: BFSN-2011-0519.R1
ISSN: 0099-0248
Fecha de publicación
2015-03-21Filiación
Univresidad de Alcalá. Departamento de Química Analítica, Química Física e Ingeniería QuímicaCita bibliográfica
Critical Reviews in Food Science and Nutrition, 2015, v. 55, n. 4, p. 521-551
Palabras clave
Peptide
Chromatography
Enzyme
ACE
Protein
Bioactivity
Proyectos
info:eu-repo/grantAgreement/MICIN//CTQ2009-09022//ES/NUEVAS ESTRATEGIAS ANALÍTICAS PARA LA DETERMINACIÓN DE ENANTIOMEROS Y PEPTIDOS BIOACTIVOS POR MICRO/NANO TÉCNICAS
info:eu-repo/grantAgreement/MICIN//CTQ2009-09022//ES/NUEVAS ESTRATEGIAS ANALÍTICAS PARA LA DETERMINACIÓN DE ENANTIOMEROS Y PEPTIDOS BIOACTIVOS POR MICRO/NANO TÉCNICAS
Tipo de documento
info:eu-repo/semantics/article
Versión
info:eu-repo/semantics/publishedVersion
Derechos
Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
© Taylor and Francis
Derechos de acceso
info:eu-repo/semantics/openAccess
Resumen
Hypertension is one of the main causes of cardiovascular diseases. Synthetic drugs inhibiting ACE activity present high effectiveness in the treatment of hypertension but cause undesirable side effects. Unlike these synthetic drugs, antihypertensive peptides do not show any adverse effect. These peptides are naturally present in some foods and since hypertension is closely related to modern diet habits, the interest for this kind of foods is increasing. Different methods for the purification, isolation, and characterization of antihypertensive peptides in foods have been developed. Nevertheless, there is no revision work summarizing and comparing these strategies. In this review, in vivo and in vitro pathways to obtain antihypertensive peptides have been summarized. The ACE mechanism and the methodologies developed to assay the ACE inhibitory activity have also been described. Moreover, a comprehensive overview on the isolation, purification, and identification techniques focusing on the discovery of new antihypertensive peptides with high activity has been included. Finally, it is worthy to highlight that the quantitation of antihypertensive peptides in foods is a new trend since genotype and processing conditions could affect their presence. Analytical methodologies using mass spectrometry constitute an interesting option for this purpose.
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