Dendrimers and dendritic materials: From laboratory to medical practice in infectious diseases
Autores
Ortega Núñez, Miguel Ángel; Guzman Merino, Alberto; Fraile Martínez, Óscar; Recio Ruiz, Judith; Pekarek, Leonel; [et al.]Identificadores
Enlace permanente (URI): http://hdl.handle.net/10017/46749DOI: 10.3390/pharmaceutics12090874
ISSN: 1999-4923
Fecha de publicación
2020-09-03Filiación
Universidad de Alcalá. Departamento de Medicina y Especialidades Médicas; Universidad de Alcalá. Departamento de Biología de Sistemas; Universidad de Alcalá. Departamento de Química Orgánica y Química InorgánicaCita bibliográfica
Pharmaceutics, 2020, v. 12, n. 9 - 874
Palabras clave
dendrimer
nanoparticle
infection
bacteria
virus
fungi
parasite
amoeba
prion
Proyectos
2017-T2/IND-5243 (Comunidad de Madrid); project NATURDEN CM-JIN-2019-001(Comunidad de Madrid); project DENDROGEL SBPLY-19-180501-000269 (Junta de Comunidades de Castilla-la Mancha).
Tipo de documento
info:eu-repo/semantics/article
Versión
info:eu-repo/semantics/publishedVersion
Derechos
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
MDPI, 2020
Derechos de acceso
info:eu-repo/semantics/openAccess
Resumen
Infectious diseases are one of the main global public health risks, predominantly caused by viruses, bacteria, fungi, and parasites. The control of infections is founded on three main pillars: prevention, treatment, and diagnosis. However, the appearance of microbial resistance has challenged traditional strategies and demands new approaches. Dendrimers are a type of polymeric nanoparticles whose nanometric size, multivalency, biocompatibility, and structural perfection offer boundlesspossibilities in multiple biomedical applications. This review provides the reader a general overview about the uses of dendrimers and dendritic materials in the treatment, prevention, and diagnosis of highly prevalent infectious diseases, and their advantages compared to traditional approaches. Examples of dendrimers as antimicrobial agents per se, as nanocarriers of antimicrobial drugs, as well as their uses in gene transfection, in vaccines or as contrast agents in imaging assays are presented.Despite the need to address some challenges in order to be used in the clinic, dendritic materials appear as an innovative tool with a brilliant future ahead in the clinical management of infectiousdiseases and many other health issues.
Ficheros en el ítem
Ficheros | Tamaño | Formato |
|
---|---|---|---|
Dendrimers-GarciaGallego-Pharm ... | 3.179Mb |
|
Ficheros | Tamaño | Formato |
|
---|---|---|---|
Dendrimers-GarciaGallego-Pharm ... | 3.179Mb |
|
Colecciones
- QUIMINOR - Artículos [235]