Azonia derivatives of the γ-carboline system. A new class of DNA intercalators
Authors
Molina Ponce, Andrés; Vaquero López, Juan J.; García Navío, José Luis; Álvarez-Builla Gómez, Julio; Rodrigo López, María Melia; [et al.]Identifiers
Permanent link (URI): http://hdl.handle.net/10017/4176DOI: 10.1016/S0960-894X(96)00243-0
ISSN: 0960-894X
Publisher
Elsevier
Date
1996Funders
Instituto de Qulmica Computacional
Bibliographic citation
Bioorganic & Medicinal Chemistry Letters, 1996, v.6, n.13, p.1453-1456
Keywords
DNA intercalators
Azonia derivatives
γ-carboline system
Project
SAF94-0280 (Comisión Intermimsterial de Ciencia y Tecnologfa-CICYT)
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1016/S0960-894X(96)00243-0Rights
© Elsevier, 1996
Access rights
info:eu-repo/semantics/openAccess
Abstract
1-Methyl-γ-carboline derivatives were transformed into the corresponding N-aminoazinium salts, which were condensed with 1,2-dicarbonyl compounds (Westphal reaction) to afford azonia derivatives with a bridgehead quaternary nitrogen atom. Some of them show DNA intercalating properties.
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- QUIMORG - Artículos [128]