High-performance liquid-chromatographic determination of the pi-values of azol-N-yl substituents
Autores
Álvarez-Builla Gómez, Julio; Crespo, Teresa; López, Raquel; Elguero, José; Toiron, Catherine; [et al.]Identificadores
Enlace permanente (URI): http://hdl.handle.net/10017/3920DOI: 10.1002/jps.2600810623
ISSN: 0022-3549
Editor
American Pharmacists Association
Wiley
Fecha de publicación
1992Patrocinadores
J. A. B., T. C., and R.L.acknowledge financial support from the Comisión lnterministerial de Ciencia y Tecnología through project. PB87-0755.
Cita bibliográfica
Journal of Pharmaceutical Sciences, 1992 v. 81, n. 6, p. 577-580
Palabras clave
Hydrophobicity measurements
Partition-coefficients
Behavior
Water
Proyectos
PB87-0755 (Comisión Interministerial de Ciencia y Tecnología-CICYT)
Tipo de documento
info:eu-repo/semantics/article
Versión
info:eu-repo/semantics/publishedVersion
Versión del editor
http://dx.doi.org/10.1002/jps.2600810623Derechos
(c) American Pharmaceutical Association, 1992
Derechos de acceso
info:eu-repo/semantics/openAccess
Resumen
The π (hydrophobic constant) values for 16 parent azoles (pyrrole, imidazole, pyrazole, four triazoles, two tetrazoles, indole, benzimidazole, 1 H and 2H-indazoles, 1H-and 2H-benzotriazoles, and carbazole) were calculated from the logarithms of the capacity factors (log k′) determined by HPLC. The values thus obtained are discussed according to an additive model in which the number and position of pyridinelike nitrogen atoms and the annelation effect are considered.
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