Synthesis and structure of new pyrido[2,3-D]pyrimidine derivatives with calcium-channel antagonist activity
Autores
Pastor del Castillo, Alfredo; Alajarín Ferrández, Luis Ramón; Vaquero López, Juan J.; Álvarez-Builla Gómez, Julio; Casa-Juana Muñoz, Miguel Fau de; [et al.]Identificadores
Enlace permanente (URI): http://hdl.handle.net/10017/3697DOI: 10.1016/S0040-4020(01)85291-1
ISSN: 0040-4020
Editor
Pergamon
Fecha de publicación
1994Patrocinadores
We gratefully acknowledge to ALTER S. A. for studentship (to A. P and R. A.) and financial support
Cita bibliográfica
Tetrahedron, 1994, v. 50, n. 27, p. 8085-8098
Palabras clave
Pyrido[2,3-D]pyrimidine derivatives
Calcium-channel
Tipo de documento
info:eu-repo/semantics/article
Versión
info:eu-repo/semantics/publishedVersion
Versión del editor
http://dx.doi.org/10.1016/S0040-4020(01)85291-1Derechos
(c) Elsevier, 1994
Derechos de acceso
info:eu-repo/semantics/openAccess
Resumen
Several series of pyrido[2,3-d]pyrimidine derivatives were synthesized by reaction of aryl methyleneacetoacetates with different aminopyrimidines. The solid-state structure of the methyl 5-(3'-chlorophenyl)-7-methyl-4-oxo-2-thioxo-1,2,3,4,5,8-hexahydropyrido[ 2,3-d]pyrimidine-6-carboxylate shows that these compounds can adopt some of the most important structural features of the 1,4-dihydropyridine calcium channel blockers. The scope and limitations of the synthetic procedure with different aminoheterocycles is presented together with the initial evaluation of their calcium antagonistic activity by comparison with the usual reference compound nifedipine.
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