Synthesis and structure of new pyrido[2,3-D]pyrimidine derivatives with calcium-channel antagonist activity
Authors
Pastor del Castillo, Alfredo; Alajarín Ferrández, Luis Ramón; Vaquero López, Juan J.; Álvarez-Builla Gómez, Julio; Casa-Juana Muñoz, Miguel Fau de; [et al.]Identifiers
Permanent link (URI): http://hdl.handle.net/10017/3697DOI: 10.1016/S0040-4020(01)85291-1
ISSN: 0040-4020
Publisher
Pergamon
Date
1994Funders
We gratefully acknowledge to ALTER S. A. for studentship (to A. P and R. A.) and financial support
Bibliographic citation
Tetrahedron, 1994, v. 50, n. 27, p. 8085-8098
Keywords
Pyrido[2,3-D]pyrimidine derivatives
Calcium-channel
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1016/S0040-4020(01)85291-1Rights
(c) Elsevier, 1994
Access rights
info:eu-repo/semantics/openAccess
Abstract
Several series of pyrido[2,3-d]pyrimidine derivatives were synthesized by reaction of aryl methyleneacetoacetates with different aminopyrimidines. The solid-state structure of the methyl 5-(3'-chlorophenyl)-7-methyl-4-oxo-2-thioxo-1,2,3,4,5,8-hexahydropyrido[ 2,3-d]pyrimidine-6-carboxylate shows that these compounds can adopt some of the most important structural features of the 1,4-dihydropyridine calcium channel blockers. The scope and limitations of the synthetic procedure with different aminoheterocycles is presented together with the initial evaluation of their calcium antagonistic activity by comparison with the usual reference compound nifedipine.
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