New bow-tie cationic carbosilane dendritic system with a curcumin core as an anti-breast cancer agent
Authors
Ortega Lopez, Paula; Mata de la Mata, Francisco Javier de la; Gómez Ramírez, Rafael; Lozano de la Cruz, TaniaIdentifiers
Permanent link (URI): http://hdl.handle.net/10017/35920DOI: DOI: 10.1039/c8nj01713a
ISSN: 1144-0546
Date
2018Embargo end date
2019-08-31Bibliographic citation
New Journal of Chemistry, 2018, v. 42, n. 14, p. 11732-11738
Keywords
curcumin
dendrimers
carbosilane, MCF-7
Antioxidant, antitumoral
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
© Royal Society of Chemistry
Access rights
info:eu-repo/semantics/openAccess
Abstract
Though curcumin has been demonstrated as highly cytotoxic towards various cancer cell lines, the major drawbacks for its use are the insolubility and instability in water to provoke low bioavailability. On the other hand, carbosilane dendritic systems with cationic charge on the surface have been studied in different biomedical applications such as antibacterial, anticancer or as non-viral vehicles for the delivery of nucleic acids. In this study, we combine both systems by synthesizing a new "bow-tie" cationic carbosilane dendrimer where curcumin is located at the core. The resulting new system is completely water-soluble, conserves the antioxidant properties and induces higher cytotoxicity against MCF-7 cancer cells than free curcumin. In addition, the effects on the cell cycle and apoptosis induction by using flow cytometry analysis are evaluated to obtain insights of the cytotoxic mechanism of action.
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