| dc.contributor.author | Díaz Martínez, Adolfo | |
| dc.contributor.author | Siro Herrero, Jorge G. | |
| dc.contributor.author | García Navío, José Luis | |
| dc.contributor.author | Vaquero López, Juan J. | |
| dc.contributor.author | Álvarez-Builla Gómez, Julio | |
| dc.date.accessioned | 2009-07-15T04:50:49Z | |
| dc.date.available | 2009-07-15T04:50:49Z | |
| dc.date.issued | 1997 | |
| dc.identifier.bibliographicCitation | Synthesis, 1997, n. 5, p. 559-562 | en |
| dc.identifier.issn | 0039-7881 | |
| dc.identifier.uri | http://hdl.handle.net/10017/3591 | |
| dc.description.abstract | A stereoselective synthesis of (R)-(-)-rolipram from L-glutamic acid is described. The key step is a stereoselective Michael addition of an arylcuprate to a modified pyroglutamic derivative which acts as the template to induce the stereoselectivity. Facile manipulation of the enantiomerically pure Michael product afforded the expected therapeutic agent. | en |
| dc.description.sponsorship | We gratefully acknowledge ZAMBON GROUP for studentships (to A. D. and J. S.) and financial support. | en |
| dc.format.mimetype | application/pdf | en |
| dc.language.iso | eng | en |
| dc.publisher | Verlag | en |
| dc.rights | (c) Wiley, 1997 | en |
| dc.subject | Glutamic acid | en |
| dc.subject | Rolipram | en |
| dc.subject | Article | en |
| dc.subject | Central nervous system disease | en |
| dc.subject | Chemical modification | en |
| dc.subject | Chirality | en |
| dc.subject | Drug synthesis | en |
| dc.subject | Enantiomer | en |
| dc.subject | Reaction analysis | en |
| dc.subject | Stereochemistry | en |
| dc.title | A stereoselective synthesis of (R)-(-)-rolipram from L-glutamic acid | en |
| dc.type | info:eu-repo/semantics/article | en |
| dc.subject.eciencia | Ciencia | es_ES |
| dc.subject.eciencia | Química orgánica | es_ES |
| dc.subject.eciencia | Science | en |
| dc.subject.eciencia | Chemistry, organic | en |
| dc.contributor.affiliation | Universidad de Alcalá. Departamento de Química Orgánica | |
| dc.relation.publisherversion | http://dx.doi.org/10.1002/chin.199741254 | |
| dc.type.version | info:eu-repo/semantics/publishedVersion | en |
| dc.identifier.doi | 10.1002/chin.199741254 | |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
