Synthesis of chiral carbosilane dendrimers with L-cysteine and N-acetyl-L-cysteine on their surface and their application as chiral selectors for enantiomer separation by capillary electrophoresis
Autores
Quintana Sánchez, Sara; Ortega Lopez, Paula; Mata de la Mata, Francisco Javier de la; Gómez Ramírez, Rafael; Marina Alegre, María Luisa; [et al.]Identificadores
Enlace permanente (URI): http://hdl.handle.net/10017/35870DOI: doi.org/10.1016/j.tetasy.2017.10.028
ISSN: 0957-4166
Fecha de publicación
2017-12-15Filiación
Universidad de Alcalá. Departamento de Química Analítica, Química Física e Ingeniería Química; Universidad de Alcalá. Departamento de Química Orgánica y Química InorgánicaCita bibliográfica
Tetrahedron: Asymmetry, 2017, v. 28, n. 12, p. 1797-1802
Palabras clave
carbosilane
dendrimers
chiral
electrophoresis
Tipo de documento
info:eu-repo/semantics/article
Versión
info:eu-repo/semantics/publishedVersion
Derechos
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
© Elsevier
Derechos de acceso
info:eu-repo/semantics/openAccess
Resumen
The synthesis of chiral carbosilane dendrimers functionalized with cysteine and Nacetylcysteine groups is presented in this work. These dendrimers were obtained through thiol-ene addition reactions and their application as chiral selectors in Capillary Electrophoresis was investigated. Four drugs used as model compounds were analyzed under different experimental conditions observing that the use of a first generation dendrimer containing 4 terminal N-Acetyl-L-cysteine groups enabled the enantiomeric discrimination of razoxane being this discrimination power similar to that obtained with other powerful chiral selectors such as cyclodextrins.
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