Synthesis of new azino fused benzimidazolium salts. A new family of DNA intercalating agents. l
Authors
Pastor Fernández, Joaquín; Siro Herrero, Jorge G.; García Navío, José Luis; Vaquero López, Juan J.; Rodrigo López, María Melia; [et al.]Identifiers
Permanent link (URI): http://hdl.handle.net/10017/3436DOI: 10.1016/0960-894X(95)00532-4
ISSN: 0960-894X
Publisher
Pergamon
Date
1995Funders
Universidad de Alcalá
Comisión Interministerial de Ciencia y Tecnología-CICYT
Bibliographic citation
Bioorganic & Medicinal Chemistry Letters, v.5, n.24, p.3043-3048
Keywords
Westphal condensation
Deoxyribonucleic-acid
Drugs
Derivatives
Kinetics
Analogs
Chemistry, Medicinal
Chemistry, Organic
Project
info:eu-repo/grantAgreement/ICYT//SAF94-0280/ES/NUEVOS AGENTES BISINTERCALANTES SELECTIVOS SOBRE AON
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1016/0960-894X(95)00532-4Rights
© Elsevier, 1995
Access rights
info:eu-repo/semantics/openAccess
Abstract
A series of new pyrido[1,2-a]- and pyridazino[1,6-a]benzimidazolium salts have been synthesized from readily available 1,3-disubstituted 2-alkylbenzimidazolium salts. Their affinity to DNA and in vitro cytotoxicity versus HT-29 have been tested. The initial results show that the title compounds are a new family of intercalating agents.
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