Activation of D1 and D2 dopamine receptors increases the activity of the somatostatin receptor-effector system in the rat frontoparietal cortex
Identificadores
Enlace permanente (URI): http://hdl.handle.net/10017/2977DOI: 10.1002/1097-4547(20001001)62:1<91::AID-JNR10>3.0.CO;2-D
ISSN: 1097-4547
Editor
Wiley-Liss
Fecha de publicación
2000Patrocinadores
We thank Martin Lexell from Centro de Lenguas Extranjeras of the Universidad de Alcala´, Angela Martı´n Espinosa for her excellent technical assistance, and Lilian Puebla and Jerry Keller for their linguistic assistance. We express our sincere thanks to Astra Ifesa (Barcelona, Spain) for the supply of raclopride and to Sandoz (Basel, Switzerland) for the supply of SMS 201-995 and SDZ 204- 090.
Cita bibliográfica
Journal of Neuroscience Research, 2000, v. 62, p. 91-98
Palabras clave
SKF 38393
Bromocriptine
SCH 23390
Raclopride
Somatostatin receptor
Adenylyl cyclase
Inositol-1,4,5-triphosphate
Rat
Frontoparietal cortex
Proyectos
PM95-0041 (Ministerio de Ciencia y Tecnología)
E007/97 (Universidad de Alcalá)
Tipo de documento
info:eu-repo/semantics/article
Versión
info:eu-repo/semantics/publishedVersion
Versión del editor
http://dx.doi.org/10.1002/1097-4547(20001001)62:1<91::AID-JNR10>3.0.CO;2-DDerechos
© Wiley-Liss, 2000
Derechos de acceso
info:eu-repo/semantics/openAccess
Resumen
The role of dopamine D1 and D2 receptor subtypes in the regulation, in vivo, of the somatostatin (SRIF) receptor-effector system in rat frontoparietal cortex was investigated. The D1-receptor agonist SKF 38393 (4 mg/kg) or the D2-receptor agonist bromocriptine (2 mg/kg), administered intraperitoneally to rats, increased the number of SRIF receptors without altering the affinity constant, an effect antagonized by both SCH 23390 (0.25 mg/kg) and raclopride (5 mg/kg), D1 and D2 receptor antagonists, respectively. These antagonists alone had no effect on [125I]Tyr3 octreotide binding to its receptors. No change in binding was detected when the dopamine agonists were added in vitro. Basal adenylyl cyclase (AC) activity was increased by SKF 38393 treatment and decreased by bromocriptine. Octreotide (SMS 201-995)-mediated inhibition of basal and forskolin-stimulated AC was increased by SKF 38393 or bromocriptine treatment. In frontoparietal cortical slices, basal inositol-1,4,5-triphosphate (IP3) levels were decreased by bromocriptine treatment but were unaffected by SKF 38393. SMS 201-995 increased the IP3 accumulation in control, SKF 38393-, and bromocriptine-treated rats. Insofar as SRIF and dopamine appear to be involved in motor regulation and could well modulate somatosensory functions in frontal and parietal cortex, respectively, heterologous receptor regulation may have important repercussions regarding the control exerted by these neurotransmitters on frontal and parietal cortical function in the intact animal. J. Neurosci. Res. 62:91–98, 2000. © 2000 Wiley-Liss, Inc.
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