Differential effects of ethanol ingestion on somatostatin content,somatostatin receptors and adenylyl cyclase activity in thefrontoparietal cortex of virgin and parturient rats
Autores
Barrios Sabador, Vicente; Puebla Jiménez, Lilian; Boyano Adánez, María del Carmen; Sanz, Manuel; Soriano Guillén, Leandro; [et al.]Identificadores
Enlace permanente (URI): http://hdl.handle.net/10017/2247DOI: 10.1016/j.lfs.2005.01.019
ISSN: 0024-3205
Editor
Elsevier
Fecha de publicación
2005Patrocinadores
Ministerio de Ciencia y Tecnología
Instituto de Salud Carlos III
Cita bibliográfica
Life Sciences, 2005, v. 77, n. 10, p. 1094 – 1105
Palabras clave
Ethanol
Somatostatin
Gestation
Frontoparietal cortex
Adenylyl cyclase
Virgin rats
Proyectos
info:eu-repo/grantAgreement/MICYT//SAF2003-08052/ES/ESTUDIO DEL SISTEMA SOMATOSTATINÉRGICO DEL SISTEMA NERVIOSO CENTRAL DE LA RATA LEWIS CON ENCEFALOMIELITIS ALÉRGICA EXPERIMENTAL
info:eu-repo/grantAgreement/ISCIII//PI02%2F1241/ES//
Tipo de documento
info:eu-repo/semantics/article
Versión
info:eu-repo/semantics/publishedVersion
Versión del editor
http://dx.doi.org/10.1016/j.lfs.2005.01.019Derechos
(c) Elsevier, 2005
Derechos de acceso
info:eu-repo/semantics/openAccess
Resumen
Chronic ethanol ingestion decreases the number of somatostatin (SRIF) receptors in the rat frontoparietal cortex and female sex hormones modulate the effects of ethanol in the brain. Therefore, we investigated the differential effects of ethanol consumption on the SRIFergic system in the frontoparietal cortex of virgin and parturient rats given ethanol in their drinking water before and during gestation. In parturient rats, ethanol consumption decreased the density of SRIF receptors (25%, p < 0.01 vs control parturient group) whereas the SRIF-like immunoreactivity (SRIF-LI) content was increased (140%, p < 0.01). In virgin rats, ethanol ingestion decreased the density of SRIF receptors (42%, p < 0.01) more than in alcoholic parturient rats. SRIF-LI levels were unaffected. The inhibitory effect of SRIF on basal and forskolin-stimulated adenylyl cyclase was significantly lower in alcoholic virgin rats as compared to alcoholic parturient rats. No differences in the levels of the G inhibitory (Gi) ¿1 and Gi¿2 proteins were observed among the experimental groups. These results suggest that gestation may confer partial resistance to the ethanol-induced effect on the SRIFergic system.
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