%0 Journal Article 
%A Baeza García, Alejandro
%A Mendiola Serena, Javier
%A Burgos García, Carolina
%A Álvarez-Builla Gómez, Julio
%A Vaquero López, Juan J.
%T Palladium-mediated C-N, C-C, and C-O functionalization of azolopyrimidines: a new total synthesis of variolin B
%D 2008
%@ 0040-4039
%U http://hdl.handle.net/10017/2653
%X A new total synthesis of the alkaloid variolin B is achieved by a selective and sequential palladium-mediated functionalization of a
trihalo-substituted pyrido[30
,20
:4,5]pyrrolo[1,2-c]pyrimidine. This intermediate is obtained by a new heterocyclization reaction between
an appropriate bromomethyl azaindole and N-tosylmethyl dichloroformimide. The methodology may be effective for the synthesis of
some analogs by substitution on the relatively unexplored C4 and C9 positions of the alkaloid.
%K Variolin B
%K Total synthesis
%K Palladium-mediated C-N, C-C and C-O; pyrido[3 ',2 ': 4,5]pyrrolo[1,2-c]pyrimidine
%K N-tosylmethyl dichloro-formimide
%K Sponge kirkpatrickia-varialosa
%K Deoxyvariolin-B
%K Bond formation
%K Alkaloids
%K Core
%K Derivatives
%K Ethers
%K Chemistry, Organic
%K Bioquímica
%K Biochemistry
%K Science
%K Ciencia
%~ Biblioteca Universidad de Alcala