RT info:eu-repo/semantics/article T1 Effects of insulin-induced hypoglycemia on somatostatin level and binding in rat cerebral cortex and hippocampus A1 Rodríguez Sánchez, María Nelly A1 Colás Escudero, María Begoña A1 Prieto Villapún, Juan Carlos A1 Arilla Ferreiro, Eduardo K1 Insulin-induced hypoglycemia K1 Somatostatin K1 Cerebral cortex K1 Hippocampus K1 Rat K1 Bioquímica K1 Biochemistry K1 Science K1 Ciencia AB The effects of severe insulin-induced hypoglycemia on somatostatin level and specific binding in the cerebral cortex and hippocampus were examined using 125I-Tyr11-somatostatin as a ligand. Severe insulin-induced hypoglycemia did not affect the level of somatostatin-like immunoreactivity in the brain areas studied. However, the number (but not the affinity) of specific somatostatin receptors was significantly decreased in membrane preparation from the hippocampus but not in the cerebral cortex at the onset of hypoglycemia coma (5-10 min). Administration of glucose at the onset of hypoglycemic coma brought about extensive recovery of hippocampal somatostatin receptor number. These results suggest that glucose modulates the somatostatin receptor in the rat hippocampus. The physiological significance of these findings remains to be clarified. PB Elsevier SN 0006-8993 YR 1989 FD 1989 LK http://hdl.handle.net/10017/6947 UL http://hdl.handle.net/10017/6947 LA eng DS MINDS@UW RD 29-mar-2024