RT info:eu-repo/semantics/article T1 Chitosan/Gamma-Alumina/Fe3O4@5-FU nanostructures as promising nanocarriers: physiochemical characterization and toxicity activity A1 Alli, Narjes A1 Pourmadadi, Mehrab A1 Yazdian, Fatemeh A1 Rashedi, Hamid A1 Díez Pascual, Ana María K1 Drug delivery K1 Cancer K1 Chitosan K1 Gamma alumina K1 Fe3O4 K1 Fluorouracil K1 Química K1 Chemistry AB Today, cancer treatment is an important issue in the medical world due to the challenges and side effects of ongoing treatment procedures. Current methods can be replaced with targeted nano-drug delivery systems to overcome such side effects. In the present work, an intelligent nano-system consisting of Chitosan (Ch)/Gamma alumina (gamma Al)/Fe3O4 and 5-Fluorouracil (5-FU) was synthesized and designed for the first time in order to influence the Michigan Cancer Foundation-7 (MCF-7) cell line in the treatment of breast cancer. Physico-chemical characterization of the nanocarriers was carried out using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), vibrating sample magnetometry (VSM), dynamic light scattering (DLS), and scanning electron microscopy (SEM). SEM analysis revealed smooth and homogeneous spherical nanoparticles. The high stability of the nanoparticles and their narrow size distribution was confirmed by DLS. The results of the loading study demonstrated that these nano-systems cause controlled, stable, and pH-sensitive release in cancerous environments with an inactive targeting mechanism. Finally, the results of MTT and flow cytometry tests indicated that this nano-system increased the rate of apoptosis induction on cancerous masses and could be an effective alternative to current treatments. SN 1420-3049 YR 2022 FD 2022-08-23 LK http://hdl.handle.net/10017/55194 UL http://hdl.handle.net/10017/55194 LA eng DS MINDS@UW RD 29-mar-2024