RT info:eu-repo/semantics/article
T1 Evaluation and Optimization of Prolonged Release Mucoadhesive Tablets of Dexamethasone for Wound Healing: In Vitro-In Vivo Profiling in Healthy Volunteers
A1 Ul Ain Javed, Qurrat
A1 Ali Syed, Muhammad
A1 Arshad, Rabia
A1 Rahdar, Abbas
A1 Irfan, Muhammad
A1 Atif Raza, Syed
A1 Shahnaz, Gul
A1 Hanif, Sana
A1 Díez Pascual, Ana María
K1 dexamethasone
K1 hemostatic
K1 wound healing
K1 salivary pharmacokinetic
K1 mucoadhesive buccal tablet
K1 in vitro-in vivo
K1 volunteer study
K1 Química
K1 Chemistry
AB The aim of the projected study was to design and develop a novel strategy for evaluating the mucoadhesive potential of polymeric tablets of dexamethasone (DXM) for local delivery against wounds. Therefore, formulations (Q1-Q7) were synthesized via direct compression method by varying the concentrations of polymers, i.e., ethyl cellulose (EC) and agar extract (AG). Moreover, the mucoadhesive polymeric tablets were characterized via physicochemical, in vitro, ex vivo and in vivo experiments. However, physicochemical characteristics such as FTIR showed no interaction with different polymeric combination. Surface pH of all formulations was normal to slightly alkaline. Highest hydration of up to 6.22% and swelling index was comprehended with maximum concentration of AG (50% of total tablet weight). Whereas, ex vivo and in vivo residence time and mucoadhesion were attributed to the increased concentrations of polymers. Moreover, Q7, (optimized formulation), containing 10% of EC and 40% of AG, exhibited maximum release of DXM (100%) over 8 h, along with sufficient mucoadhesive strength up to 11.73 g, following first-order kinetics having r(2) value of 0.9778. Hemostatic effects and epithelialization for triggering and promoting wound healing were highly pronounced in cases of Q7. Furthermore, in vivo residence time was 7.84 h followed by salivary drug concentration (4.2 mu g/mL). However, mucoadhesive buccal tablets showed stability for 6 months, thus following the standardization (ICH-Iva) stability zone. In summary, DXM mucoadhesive tablets seem to be an ideal candidate for eradication of wound infections via local targeted delivery.
SN 1999-4923
YR 2022
FD 2022-04-07
LK http://hdl.handle.net/10017/55098
UL http://hdl.handle.net/10017/55098
LA eng
NO A
DS MINDS@UW
RD 24-abr-2024