RT info:eu-repo/semantics/article
T1 Effect of Kidney Transplantation on Accelerated Immunosenescence and Vascular Changes Induced by Chronic Kidney Disease.
A1 Ceprían, Noemí
A1 González De Pablos, Ignaco
A1 Oliva, Carlos
A1 Figuer Rubio, Andrea
A1 Praga, Manuel
A1 Alique Aguilar, Matilde
A1 Ramírez Chamond, Manuel Rafael
A1 Morales, Enrique
A1 Carracedo Añón, Julia María
A1 Valera, Gemma
A1 Caro, Jara
A1 Yuste, Claudia
A1 Serroukh, Nadia
K1 Chronic kidney disease
K1 Immunity
K1 Immunosenescence
K1 Microvesicles
K1 Renal transplantation
K1 Medicina
K1 Medicine
AB Kidney transplantation is the best option for patients with end-stage renal disease. Despite the improvement in cardiovascular burden (leading cause of mortality among patients with chronic kidney disease), cardiovascular adverse outcomes related to the inflammatory process remain a problem. Thus, the aim of the present study was to characterize the immune profile and microvesicles of patients who underwent transplantation. We investigated the lymphocyte phenotype (CD3, CD4, CD8, CD19, and CD56) and monocyte phenotype (CD14, CD16, CD86, and CD54) in peripheral blood, and endothelium-derived microvesicles (annexin V+CD31+CD41&-) in plasma of patients with advanced chronic kidney disease (n = 40), patients with transplantation (n = 40), and healthy subjects (n = 18) recruited from the University Hospital "12 de Octubre" (Madrid, Spain). Patients with kidney transplantation had B-cell lymphopenia, an impairment in co-stimulatory (CD86) and adhesion (CD54) molecules in monocytes, and a reduction in endothelium-derived microvesicles in plasma. The correlations between those parameters explained the modifications in the expression of co-stimulatory and adhesion molecules in monocytes caused by changes in lymphocyte populations, as well as the increase in the levels of endothelial-derived microvesicles in plasma caused by changes in lymphocyte and monocytes populations. Immunosuppressive treatment could directly or indirectly induce those changes. Nevertheless, the particular characteristics of these cells may partly explain the persistence of cardiovascular and renal alterations in patients who underwent transplantation, along with the decrease in arteriosclerotic events compared with advanced chronic kidney disease. In conclusion, the expression of adhesion molecules by monocytes and endothelial-derived microvesicles is related to lymphocyte alterations in patients with kidney transplantation.
SN 2296-858X
YR 2021
FD 2021-09-27
LK http://hdl.handle.net/10017/51279
UL http://hdl.handle.net/10017/51279
LA eng
NO Instituto de Salud Carlos III
DS MINDS@UW
RD 19-abr-2024