RT info:eu-repo/semantics/article
T1 Hypoxia-Inducible Factor-1alfa: The Master Regulator of Endothelial Cell Senescence in Vascular Aging
A1 Alique Aguilar, Matilde
A1 Sánchez-López E, Elsa
A1 Bodega Magro, Guillermo
A1 Giannarelli, Chiara
A1 Carracedo Añón, Julia María
A1 Ramírez Chamond, Manuel Rafael
K1 Hypoxia-inducible factor-1alfa (HIF1alfa)
K1 Vascular aging
K1 Senescent cells
K1 Endothelial cells
K1 Vascular smooth muscle cells
K1 Atherosclerosis
K1 Extracellular vesicles
K1 Medicina
K1 Medicine
AB Aging is one of the hottest topics in biomedical research. Advances in research andmedicine have helped to preserve human health, leading to an extension of life expectancy. However,the extension of life is an irreversible process that is accompanied by the development of aging-relatedconditions such as weakness, slower metabolism, and sti ness of vessels. It also debated thataging can be considered an actual disease with aging-derived comorbidities, including cancer orcardiovascular disease. Currently, cardiovascular disorders, including atherosclerosis, are consideredas premature aging and represent the first causes of death in developed countries, accounting for 31%of annual deaths globally. Emerging evidence has identified hypoxia-inducible factor-1  as a criticaltranscription factor with an essential role in aging-related pathology, in particular, regulating cellularsenescence associated with cardiovascular aging. In this review, we will focus on the regulationof senescence mediated by hypoxia-inducible factor-1  in age-related pathologies, with particularemphasis on the crosstalk between endothelial and vascular cells in age-associated atheroscleroticlesions. More specifically, we will focus on the characteristics and mechanisms by which cells withinthe vascular wall, including endothelial and vascular cells, achieve a senescent phenotype.
SN 2073-4409
YR 2020
FD 2020-01-20
LK http://hdl.handle.net/10017/51267
UL http://hdl.handle.net/10017/51267
LA eng
NO Instituto de Salud Carlos III
DS MINDS@UW
RD 20-abr-2024