RT info:eu-repo/semantics/article
T1 Endothelial Senescence and the Chronic Vascular Diseases: Challenges and Therapeutic Opportunities in Atherosclerosis
A1 Alique Aguilar, Matilde
A1 Ceprían, Noemí
A1 Ramírez Chamond, Manuel Rafael
A1 Figuer Rubio, Andrea
A1 Valera, Gemma
A1 Bodega Magro, Guillermo
K1 Atherosclerosis
K1 Cellular senescence
K1 Endothelial senescence
K1 Extracellular vesicles
K1 Inflammation
K1 Senolityc
K1 Fisiología
K1 Physiology
AB Atherosclerosis is probably one of the paradigms of disease linked to aging. Underlying the physiopathology of atherosclerosis are cellular senescence, oxidative stress, and inflammation. These factors are increased in the elderly and from chronic disease patients. Elevated levels of oxidative stress affect cellular function and metabolism, inducing senescence. This senescence modifies the cell phenotype into a senescent secretory phenotype. This phenotype activates immune cells, leading to chronic systemic inflammation. Moreover, due to their secretory phenotype, senescence cells present an increased release of highlighted extracellular vesicles that will change nearby/neighborhood cells and paracrine signaling. For this reason, searching for specific senescent cell biomarkers and therapies against the development/killing of senescent cells has become relevant. Recently, senomorphic and senolityc drugs have become relevant in slowing down or eliminating senescence cells. However, even though they have shown promising results in experimental studies, their clinical use is still yet to be determined
SN 2075-4426
YR 2022
FD 2022-02-04
LK http://hdl.handle.net/10017/51249
UL http://hdl.handle.net/10017/51249
LA eng
NO Instituto de Salud Carlos III
DS MINDS@UW
RD 18-abr-2024