RT info:eu-repo/semantics/article
T1 Dimerization inhibitors of HIV-1 reverse transcriptase, protease and integrase: A single mode of inhibition for the three HIV enzymes?
A1 Camarasa Rius, María José
A1 Velázquez Díaz, Sonsoles
A1 San Félix García, Ana
A1 Pérez Pérez, María Jesús
A1 Gago Badenas, Federico
K1 HIV-1
K1 Reverse transcriptase
K1 Integrase
K1 Protease
K1 Ciencia
K1 Farmacología
K1 Science
K1 Pharmacology
AB The genome of human immunodeficiency virus type 1 (HIV-1) encodes 15 distinct proteins, three of which provide essential enzymatic functions: a reverse transcriptase (RT), an integrase (IN), and a protease (PR). Since these enzymes are all homodimers, pseudohomodimers or multimers, disruption of protein-protein interactions in these retroviral enzymes may constitute an alternative way to achieve HIV-1 inhibition. A growing number. of dimerization inhibitors for these enzymes is being reported. This mini review summarizes some approaches that have been followed for the development of compounds that inhibit those three enzymes by interfering with the dimerization interfaces between the enzyme subunits. (c) 2006 Elsevier B.V. All rights reserved.
PB Elsevier
YR 2006
FD 2006
LK http://hdl.handle.net/10017/5071
UL http://hdl.handle.net/10017/5071
LA eng
DS MINDS@UW
RD 19-abr-2024