RT info:eu-repo/semantics/article
T1 Novel Perspectives towards RNA-Based Nano-Theranostic Approaches for Cancer Management
A1 Arshad, Rabia
A1 Fatima, Iqra
A1 Sargazi, Saman
A1 Rahdar, Abbas
A1 Karamzadeh-Jahromi, Milad
A1 Pandey, Sadanand
A1 Díez Pascual, Ana María
K1 RNA nanotechnology
K1 Cancer
K1 Theranostic
K1 Nano-biosensor
K1 Química
K1 Chemistry
AB In the fight against cancer, early diagnosis is critical for effective treatment. Traditional cancer diagnostic technologies, on the other hand, have limitations that make early detection difficult. Therefore, multi-functionalized nanoparticles (NPs) and nano-biosensors have revolutionized the era of cancer diagnosis and treatment for targeted action via attaching specified and biocompatible ligands to target the tissues, which are highly over-expressed in certain types of cancers. Advancements in multi-functionalized NPs can be achieved via modifying molecular genetics to develop personalized and targeted treatments based on RNA interference. Modification in RNA therapies utilized small RNA subunits in the form of small interfering RNAs (siRNA) for overexpressing the specific genes of, most commonly, breast, colon, gastric, cervical, and hepatocellular cancer. RNA-conjugated nanomaterials appear to be the gold standard for preventing various malignant tumors through focused diagnosis and delivering to a specific tissue, resulting in cancer cells going into programmed death. The latest advances in RNA nanotechnology applications for cancer diagnosis and treatment are summarized in this review
SN 2079-4991
YR 2021
FD 2021-12-08
LK http://hdl.handle.net/10017/50163
UL http://hdl.handle.net/10017/50163
LA eng
NO Comunidad de Madrid
DS MINDS@UW
RD 20-abr-2024