RT info:eu-repo/semantics/article
T1 Enantioselective Copper-Catalyzed Synthesis of Trifluoromethyl-Cyclopropylboronates
A1 Altarejos Salido, Julia
A1 Sucunza Sáenz, David
A1 Vaquero López, Juan J.
A1 Carreras Pérez Aradros, Javier
K1 (Trifluoromethyl)cyclopropylboronates
K1 Enantioselective cyclopropanation
K1 Trifluorodiazoethane
K1 Alkenyl boronates
K1 Copper catalysis
K1 Trifluoromethylcyclopropanes
K1 Química
K1 Chemistry
AB A copper-catalyzed enantioselective cyclopropanation involving trifluorodiazoethane in the presence of alkenyl boronates has been developed. This transformation enables the preparation of 2-substituted-3-(trifluoromethyl)cyclopropylboronates with high levels of stereocontrol. The products are valuable synthetic intermediates by transformation of the boronate group. This methodology can be applied to the synthesis of novel trifluoromethylated analogues of trans-2-arylcyclopropylamines, which are prevalent motifs in biologically active compounds.
SN 1523-7060
YR 2021
FD 2021-07-28
LK http://hdl.handle.net/10017/49328
UL http://hdl.handle.net/10017/49328
LA eng
DS MINDS@UW
RD 20-abr-2024