RT info:eu-repo/semantics/article
T1 Regiodivergent Electrophilic Cyclizations of Alkynylcyclobutanes for the Synthesis of Cyclobutane-Fused O-Heterocycles
A1 Garre Hernández, María Soledad
A1 Sucunza Sáenz, David
A1 Aguilar, Enrique
A1 García García, Patricia
A1 Vaquero López, Juan J.
K1 Cyclobutane
K1 dihydropyran
K1 methylenetetrahydrofuran
K1 gold
K1 iodine
K1 electrophilic cyclization
K1 Química
K1 Chemistry
AB Cyclobutane-fused dihydropyrans and methylenetetrahydrofurans are highly interesting cores found in numerous natural products. Both these cores are selectively prepared from a common alkynylcyclobutane precursor bearing an appended hydroxyl group herein. Thus, cyclobutane-fused dihydropyrans can be obtained by a selective 6-endo-dig iodocyclization, whereas gold-catalyzed 5-exo-dig cycloisomerization provides a bicyclic core containing a methylenetetrahydrofuran moiety as major product. Several cyclobutane-fused O-heterocycles with diverse substituents are synthesized following the reported methodology
SN 0022-3263
YR 2019
FD 2019-05-03
LK http://hdl.handle.net/10017/43792
UL http://hdl.handle.net/10017/43792
LA eng
DS MINDS@UW
RD 26-abr-2024