RT info:eu-repo/semantics/article
T1 Optimized synthesis of di, tri and tetrafused pyridazinium cations
A1 Siro Herrero, Jorge G.
A1 Ramos González, Andrés
A1 Vaquero López, Juan J.
A1 Álvarez-Builla Gómez, Julio
A1 García Navío, José Luis
K1 Westphal
K1 Condensations
K1 Polycyclic heterocyclic ions
K1 Computer-assisted methods
K1 Ciencia
K1 Química orgánica
K1 Science
K1 Chemistry, organic
AB By combining two complementary statistical techniques (fractional factorial experimental design and simplex operation) the synthesis of the parent pyrido[1,2-b]-pyridazinium cation has been successfully carried out (the yield was improved from less than 10 to 65%) by basic condensation of 2-methyl-1-aminopyridinium mesitylenesulfonate and [1,4]dioxane-2,3-diol. Using the optimized reaction conditions, other related heterocyclic cations could be prepared, and two interesting examples are now reported.
PB Elsevier
SN 0040-4020
YR 2000
FD 2000
LK http://hdl.handle.net/10017/4192
UL http://hdl.handle.net/10017/4192
LA eng
NO Ministerio de Educación y Ciencia
DS MINDS@UW
RD 26-abr-2024