RT info:eu-repo/semantics/article
T1 Antibacterial Effect of Carbosilane  Metallodendrimers in Planktonic Cells of  Gram-Positive and Gram-Negative Bacteria and  Staphylococcus aureus Biofilm
A1 Llamazares Cantalejo, Celia
A1 Sanz del Olmo, Natalia
A1 Ortega Lopez, Paula
A1 Gómez Ramírez, Rafael
A1 Soliveri de Carranza, Juan
A1 Mata de la Mata, Francisco Javier de la
A1 García Gallego, Sandra
A1 Copa Patiño, José Luis
K1 dendrimer
K1 metallodendrimer
K1 metal
K1 copper
K1 ruthenium
K1 antibacterial
K1 biofilm
K1 Staphylococcus aureus
K1 Escherichia coli
K1 Biología y Biomedicina/Biología
K1 Biology
K1 Química
K1 Chemistry
AB Antibiotic resistance is currently one of the main threats to public health security. Biofilm formation is a resistance mechanism that is responsible for most human bacterial infections and requires new and effective therapeutic approaches, such as those provided by nanotechnology. In this work, the antibacterial effect of carbosilane metallodendrimers with different metals (copper(II)and ruthenium(II)), ligands (chloride and nitrate) and generations (generation 0, 1 and 2) has been studied using planktonic Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. Furthermore, the ability of the metallodendrimers to avoid the formation of S. aureus biofilms was also evaluated. The results showed a promising biocide activity in both types of planktonic bacteria, especially for first-generation dendrimers, which arises from the metal complexation to the dendrimer. Cu(II) metallodendrimers require lower concentration than Ru(II) counterpart to inhibit the production of S. aureus biofilms, but none produce hemolysis at the inhibitory concentrations andcan be safely used as antibacterial agents. In particular, the first-generation Cu(II) metallodendrimer with nitrate ligands displayed the most promising properties to continue with further studies in both planktonic cells and biofilms.
SN 2218-273X
YR 2019
FD 2019-08-23
LK http://hdl.handle.net/10017/39787
UL http://hdl.handle.net/10017/39787
LA eng
DS MINDS@UW
RD 20-abr-2024